Outcomes of Surgical Treatment of Primary Signet Ring Cell Carcinoma of the Colon and Rectum: 22 Cases Reviewed With Literature

Abstract Colorectal primary signet ring cell carcinoma (PSRCCR) is a rare entity with a dismal prognosis, mainly because of delayed diagnosis. The objective of this study was to investigate the clinicopathologic features and prognostic factors for PSRCCR. This is a retrospective study including the data of 22 patients with PSRCCR who underwent surgery. Patients were categorized by age, sex, tumor site, and stage. Fifteen patients were male. Median age was 40 years. Sites for metastases were lymph nodes (86.4%), peritoneum (40.9%), and liver (9.1%). Most of the patients (91%) had stage III or IV tumors. The rates of curative and palliative resections performed were equal. Mean overall survival and mean progression-free survival times were found to be 33.3 ± 7.1 months (95% confidence interval, 19.4–47.2 months) and 11.8 ± 3.5 months (95% confidence interval, 4.9–18.7 months), respectively. It was concluded that site of the tumor, presence of bowel obstruction, peritoneum and lung metastases, adjacent organ infiltration, TNM stage, and efficiency of surgery have significant effects on survival. All in all, these aggressive tumors are generally diagnosed at advanced stages. Depending on the situation, survival is shorter. A high degree of vigilance is required for these patients to avoid the negative impact of late diagnosis on survival.

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Anatomic Subsites and Prognosis of Gastric Signet Ring Cell Carcinoma: A SEER Population-based 1:1 Propensity-matched Study

10.21203/rs.3.rs-403278/v1 ◽

2021 ◽

Author(s):

Yangyang Xie ◽

Xue Song ◽

Haimin Jin ◽

Zhongkai Ni ◽

Xiaowen Li ◽

...

Keyword(s):

Cell Carcinoma ◽

Mortality Risk ◽

Cox Regression ◽

Signet Ring Cell Carcinoma ◽

Signet Ring Cell ◽

Survival Prediction ◽

Cancer Specific Survival ◽

Dismal Prognosis ◽

Signet Ring ◽

Ring Cell

Abstract Background: The dismal prognosis of gastric signet ring cell carcinoma (GSRC) is a global problem. The current study is conducted to comprehensively evaluate clinicopathological features and survival outcomes in GSRC patients stratified by anatomic subsites. Then predictive nomograms are constructed and validated to improve the effectiveness of personalized management.Method: The patients diagnosed with GSRC were recruited from the online SEER database. The influence of anatomic subsites on overall survival (OS) and cancer-specific survival (CSS) was evaluated using multivariate Cox regression and Kaplan-Meier analysis. Then we employed propensity score matching (PSM) technique to decrease selection bias and balance patients’ epidemiological factors. Predictive nomograms were constructed and validated.Results: Multivariate Cox regression demonstrated that the patients with overlapping gastric cancer (OGC) suffered the highest mortality risk for OS (HR, 1.29; 95%CI, 1.23-1.36; P<0.001) and CSS (HR, 1.33; 95%CI, 1.28-1.37; P<0.001). Age, TNM stage, tumor localization, tumor size, surgery and chemotherapy presented a highly significant relationship with OS and CSS. Following subgroup and PSM analysis, OGC patients were confirmed to have the worst OS and CSS. Then nomograms predicting 6 months, 12 months and 36 months OS and CSS were constructed. The calibration curves and reveiver operating characteristic curves demonstrated the great performance of the nomograms.Conclusion: We identified anatomic subsites as a predictor of survival in those with GSRC. Patients with OGC suffered the highest mortality risk. The proposed nomograms allowed a relatively accurate survival prediction for GSRC patients.

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Clinicopathological Characteristics and Prognosis of Signet Ring Cell Carcinoma of the Gallbladder

10.21203/rs.3.rs-154548/v1 ◽

2021 ◽

Author(s):

Jiayi Li ◽

Jun You ◽

Yanming Zhou ◽

Shijie Wang

Keyword(s):

Cell Carcinoma ◽

Cox Regression ◽

Multivariable Analysis ◽

Signet Ring Cell Carcinoma ◽

Signet Ring Cell ◽

Advanced Tumor Stage ◽

Dismal Prognosis ◽

Advanced Tumor ◽

Signet Ring ◽

Ring Cell

Abstract Background Signet ring cell carcinoma (SRC) is a rare histological subtype of gallbladder adenocarcinoma. The current study evaluates the clinicopathologic features and prognosis of SRC.Methods Patients with adenocarcinoma of the gallbladder were identified in the Surveillance, Epidemiology, and End Results database from 1973 to 2016. Overall survival (OS) was assessed using Cox regression method.Results Of 22,781 gallbladder adenocarcinomas retrieved, 377 (1.7%) were SRC and the other 22,404 were non-SRC. SRC was more significantly associated with older age, female gender, poor differentiation, advanced tumor stage, lymph node metastasis, distant metastasis, and advanced AJCC stage. The 1-, 2- and 5-year OS was 28.1%, 16.8% and 7.2% for SRC vs. 34.9%, 23.1% and 13.2% for non-SRC, respectively (P = 0.002). Multivariable analysis showed that the SRC histology was independently associated with a dismal prognosis (hazard ratio [HR] 1.256, P = 0.021). Surgery in combination with chemotherapy improved OS of gallbladder SRC patients compared with surgery alone (HR 0.726, P = 0.036) or chemotherapy alone (HR 0.433, P < 0.001). Conclusion Patients with SRC of the gallbladder have distinct clinicopathological features with poor prognosis. Surgery in combination with chemotherapy can improve survival.

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Signet ring cell carcinoma of the ampulla of Vater

10.26226/morressier.578f37fad462b8028d88fdf7 ◽

2016 ◽

Author(s):

Nihed Abdessayed

Keyword(s):

Cell Carcinoma ◽

Ampulla Of Vater ◽

Signet Ring Cell Carcinoma ◽

Signet Ring Cell ◽

Signet Ring ◽

Ring Cell

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Primary signet‐ring cell carcinoma of the lung in an HIV‐positive patient

Thoracic Cancer ◽

10.1111/1759-7714.13887 ◽

2021 ◽

Vol 12 (7) ◽

pp. 1122-1125

Author(s):

Alberto Testori ◽

Gianluca Perroni ◽

Camilla De Carlo ◽

Alessandro Crepaldi ◽

Marco Alloisio ◽

...

Keyword(s):

Cell Carcinoma ◽

Signet Ring Cell Carcinoma ◽

Signet Ring Cell ◽

Positive Patient ◽

Hiv Positive ◽

Signet Ring ◽

Ring Cell

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Primary Signet Ring Cell/Histiocytoid Carcinoma of the Eyelid: Somatic Mutations in CDH1 and Other Clinically Actionable Mutations Imply Early Use of Targeted Agents

Current Oncology ◽

10.3390/curroncol28010090 ◽

2021 ◽

Vol 28 (1) ◽

pp. 918-927

Author(s):

Lei-Chi Wang ◽

Tai-Chi Lin ◽

Yi-Chen Yeh ◽

Hsiang-Ling Ho ◽

Chieh-Chih Tsai ◽

...

Keyword(s):

Next Generation Sequencing ◽

Cell Carcinoma ◽

Tumor Tissue ◽

Signet Ring Cell Carcinoma ◽

Signet Ring Cell ◽

Next Generation ◽

Signet Ring ◽

Ring Cell ◽

Generation Sequencing ◽

E Cadherin

Primary signet ring cell/histiocytoid carcinoma of the eyelid is a rare ocular malignancy and its diagnosis is often delayed. This neoplasm presents as an insidious, diffusely infiltrative mass in the periocular area that later infiltrates the orbit. An exenteration is usually indicated; however, nearly one-third of patients develop local recurrence or metastasis. Morphologically, it resembles signet ring cell carcinoma of the stomach and breast, raising the possibility of mutations in CDH1, the gene encoding E-cadherin. To determine whether primary signet ring cell/histiocytoid carcinoma harbors the CDH1 mutation or other actionable mutations, we analyzed the tumor tissue via next-generation sequencing. We identified only one case of primary signet ring cell carcinoma of the eyelid with adequate DNA quality for sequencing from the pathological archive during the period 2000 to 2020. A comprehensive evaluation including histopathology, immunohistochemistry, and next-generation sequencing assay was performed on tumor tissue. Immunohistochemically, the tumor exhibited E-cadherin membranous staining with the aberrant cytoplasmic staining of β-catenin. Using next-generation sequencing, we demonstrated the mutation in the CDH1 gene. In addition, other clinically actionable mutations including ERBB2 and PIK3CA were also detected. The alterations in other actionable genes indicate a need for larger studies to evaluate the pathogenesis and potential therapies for primary signet ring cell/histiocytoid carcinoma of the eyelid.

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Fundic Gland Polyp With Parietal Cell Vacuolation Mimicking Signet Ring Cell Carcinoma

International Journal of Surgical Pathology ◽

10.1177/1066896921994183 ◽

2021 ◽

pp. 106689692199418

Author(s):

John D. Coyne ◽

S. Thampy

Keyword(s):

Proton Pump Inhibitor ◽

Cell Carcinoma ◽

Parietal Cell ◽

Signet Ring Cell Carcinoma ◽

Signet Ring Cell ◽

Fundic Gland ◽

Fundic Gland Polyp ◽

Signet Ring ◽

Ring Cell

Pseudo-signet ring parietal cell vacuolation has been described as a mimic of invasive signet ring cell carcinoma. Moreover, signet ring cell carcinoma has been described in a fundic gland polyp. This case demonstrates parietal cell vacuolation in a fundic gland polyp in a patient on a long-term proton pump inhibitor.

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Protein profiling reveals the characteristic changes of the complement cascade pathway in the tissues of gastric signet ring cell carcinoma

Molecular & Cellular Proteomics ◽

10.1016/j.mcpro.2021.100068 ◽

2021 ◽

pp. 100068

Author(s):

Yang Fan ◽

Bin Bai ◽

Yuting Liang ◽

Yan Ren ◽

Yanxia Liu ◽

...

Keyword(s):

Cell Carcinoma ◽

Signet Ring Cell Carcinoma ◽

Signet Ring Cell ◽

Protein Profiling ◽

Complement Cascade ◽

Signet Ring ◽

Ring Cell

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A Signet Ring Cell Carcinoma Presented as Refractory Acquired Thrombotic Thrombocytopenic Purpura

Case Reports in Oncology ◽

10.1159/000510745 ◽

2020 ◽

Vol 13 (3) ◽

pp. 1368-1372

Author(s):

Umit Yavuz Malkan ◽

Murat Albayrak ◽

Hacer Berna Ozturk ◽

Merih Reis Aras ◽

Bugra Saglam ◽

...

Keyword(s):

Cell Carcinoma ◽

Plasma Exchange ◽

Thrombotic Thrombocytopenic Purpura ◽

Unknown Origin ◽

Signet Ring Cell Carcinoma ◽

Signet Ring Cell ◽

Thrombocytopenic Purpura ◽

Signet Ring ◽

Gastric Endoscopy ◽

Ring Cell

Microangiopathic hemolytic anemia (MAHA) can be observed as a paraneoplastic syndrome (PS) in certain tumors. MAHA-related signet ring cell carcinoma (SRCC) of an unknown origin is very infrequent. Herein we present a SRCC case presented with refractory acquired thrombotic thrombocytopenic purpura (TTP). A 35-year-old man applied to the emergency service with fatigue and headache. His laboratory tests resulted as white blood cell 9,020/µL, hemoglobin 3.5 g/dL, platelet 18,000/µL. Schistocytes, micro-spherocytes, and thrombocytopenia were observed in his blood smear. MAHA was present and he was considered as having TTP. Plasma exchange treatment was initiated; however, he was refractory to this treatment. Thorax and abdomen computerized tomography revealed thickening of minor curvature in stomach corpus with hepatogastric and paraceliac lymphadenopathy. Bone marrow (BM) investigation by our clinic resulted as the metastasis of adenocarcinoma. Ulceration and necrosis were observed by gastric endoscopy procedure. Biopsy was taken during endoscopic intervention, which resulted as SRCC. MAHA may be seen as a PS in some tumors, especially gastric cancers. Tumor-related MAHA is generally accompanied by BM metastases. As a result, BM investigation may be used as the main diagnostic method to find the underlying cancer. The clinical course of cases with tumor-related MAHA is usually poor, and these cases are usually refractory to plasma exchange treatment. In conclusion, physicians should suspect a malignancy and BM involvement when faced with a case of refractory TTP.

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