The new species described here, Artemisia estesii, belongs to the Artemisia ludoviciana Nutt. species’ group in the Pacific Northwest. It was shown by J.R. Estes (1968a, 1969) to be a diploid member of an otherwise polyploid hybrid complex, with most of its related species and subspecies occurring at the tetraploid and hexaploid levels. Artemisia estesii is recognized by its underground and emergent, over-wintering, basal shoots, which are homologs of the elongate, underground rhizomes found in other herbaceous Artemisia species. Its regularly lobed leaf blades, with usually a broad rachis, differ from subspecies of A. ludoviciana in eastern Oregon. It occupies a narrow zone of streambank vegetation along the central Deschutes River and extends eastward along the lower Crooked River. Disjunct populations are known from Wheeler County and Lake County.