EVAIUATION OF THE GENOTOXIC EFFECTS OF SOME BIOLOGICALY ACTIVE SUBSTANCES

There are more and more substances coming in contact with people and environment, they have got genotoxic features, which cause hereditary illnesses and tumors. Though cancer treatment becomes more and more effective, still the amount of deaths from tumors caused by harmful substances are increasing from year to year. To reduce the effects of these harmful substances, they should be detected and avoided.To perform experiments using Saccaromyces cerevisiae mutagenicity testsystem and Escerichia coli SOS chromotest to find out biologically active substances used in labs and industry, also its mixture or separate compounds possessing genotoxicity with other substances. The genotoxic properties of 11 substances were studied. Results showed that formaldehyde, urethane, acridine orange, acridine yellow, furazolidone, nalidixic acid, hydrogen peroxide, potassium bichromate, was a strong inducers of the genotoxic disorders.