rosenthal fibers
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2019 ◽  
Vol 79 (1) ◽  
pp. 113-117 ◽  
Author(s):  
Cassie MacRae ◽  
Hemant Varma

Abstract Hydrocephalus is a rare and devastating complication of mumps encephalitis. The histopathological correlates of mumps infection in central nervous system tissues are not well-characterized. We present the case of a 54-year-old patient who suffered long-term neuropsychiatric sequelae and hydrocephalus as a consequence of a childhood mumps infection. Brain autopsy revealed significant dilation of the lateral and third ventricles. Aqueductal stenosis was not observed on premortem imaging or on gross examination. Histology revealed loss of ependymal epithelium throughout the aqueduct and ventricular system. Macrophage conglomerates were identified within the cerebral aqueduct at the level of the pons in addition to subjacent periaqueductal gliosis and scattered Rosenthal fibers. Together, these findings support primary ependymal injury as a pathophysiological mechanism in the development of chronic hydrocephalus following mumps infection. Finally, we review the existing literature and discuss potential mechanisms of disease.



Author(s):  
Alexander A. Sosunov ◽  
Guy M. McKhann ◽  
James E. Goldman


2016 ◽  
Vol 15 (7) ◽  
pp. 2265-2282 ◽  
Author(s):  
Michael R. Heaven ◽  
Daniel Flint ◽  
Shan M. Randall ◽  
Alexander A. Sosunov ◽  
Landon Wilson ◽  
...  


2015 ◽  
Vol 33 (1) ◽  
pp. 35-39 ◽  
Author(s):  
Xiaomei Ma ◽  
Yin Wang ◽  
Huimin Liu ◽  
Hongyu Yu ◽  
Jin He
Keyword(s):  


2015 ◽  
Vol 117 (8) ◽  
pp. 696-704 ◽  
Author(s):  
Martha Lilia Tena-Suck ◽  
Andrea Y. Morales-del Ángel ◽  
María Elena Hernández-Campos ◽  
Francisca Fernández-Valverde ◽  
Alma Ortíz-Plata ◽  
...  


2015 ◽  
Vol 2 (3) ◽  
Author(s):  
Martha Lilia Tena-Suck ◽  
Andrea Yosajany Morales del Ángel ◽  
Lilia Edith Corona ◽  
Armando Saúl Ruiz-Treviño ◽  
Ángel Vagas-Sánchez ◽  
...  


2014 ◽  
Vol 24 (2) ◽  
pp. 146-154 ◽  
Author(s):  
Martha Lilia Tena-Suckmaria ◽  
Elena Hernández-Campos ◽  
Citalaltepetl Salinas-Lara ◽  
Manuel Castillejos-López
Keyword(s):  


Apmis ◽  
2013 ◽  
Vol 122 (1) ◽  
pp. 76-80 ◽  
Author(s):  
Tulen Pekny ◽  
Maryam Faiz ◽  
Ulrika Wilhelmsson ◽  
Maurice A. Curtis ◽  
Radoslav Matej ◽  
...  


2013 ◽  
pp. n/a-n/a
Author(s):  
Yasuo Sugita ◽  
Shinji Nakashima ◽  
Koichi Ohshima ◽  
Mizuhiko Terasaki ◽  
Motohiro Morioka


2011 ◽  
Vol 49 (2) ◽  
pp. 248-254 ◽  
Author(s):  
A. E. Kessell ◽  
J. W. Finnie ◽  
J. Manavis ◽  
G. D. Cheetham ◽  
P. C. Blumbergs

We report an encephalomyelopathy in three 18-month-old Merino sheep with features of adult-onset Alexander’s disease (AD), a human primary astrocytic disorder. The signature histologic finding was the presence of numerous hypereosinophilic, intra-astrocytic inclusions (Rosenthal fibers), mainly in perivascular, subpial, and subependymal sites, especially in the caudal brain stem and spinal cord. Although AD usually results from mutations in the glial fibrillary acidic protein ( GFAP) gene, no such mutation was detected in these sheep. However, the annual clinical presentation of this disorder in a few sheep in the affected flock is suggestive of a familial pattern of occurrence.



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