Quasisymmetric orbit-flexibility of multicritical circle maps

Two given orbits of a minimal circle homeomorphism f are said to be geometrically equivalent if there exists a quasisymmetric circle homeomorphism identifying both orbits and commuting with f. By a well-known theorem due to Herman and Yoccoz, if f is a smooth diffeomorphism with Diophantine rotation number, then any two orbits are geometrically equivalent. It follows from the a priori bounds of Herman and Świątek, that the same holds if f is a critical circle map with rotation number of bounded type. By contrast, we prove in the present paper that if f is a critical circle map whose rotation number belongs to a certain full Lebesgue measure set in $(0,1)$ , then the number of equivalence classes is uncountable (Theorem 1.1). The proof of this result relies on the ergodicity of a two-dimensional skew product over the Gauss map. As a by-product of our techniques, we construct topological conjugacies between multicritical circle maps which are not quasisymmetric, and we show that this phenomenon is abundant, both from the topological and measure-theoretical viewpoints (Theorems 1.6 and 1.8).

Cross-frequency coupling explains the preference for simple ratios in rhythmic behaviour and the relative stability across non-synchronous patterns

Rhythms are important for understanding coordinated behaviours in ecological systems. The repetitive nature of rhythms affords prediction, planning of movements and coordination of processes within and between individuals. A major challenge is to understand complex forms of coordination when they differ from complete synchronization. By expressing phase as ratio of a cycle, we adapted levels of the Farey tree as a metric of complexity mapped to the range between in-phase and anti-phase synchronization. In a bimanual tapping task, this revealed an increase of variability with ratio complexity, a range of hidden and unstable yet measurable modes, and a rank-frequency scaling law across these modes. We use the phase-attractive circle map to propose an interpretation of these findings in terms of hierarchical cross-frequency coupling (CFC). We also consider the tendency for small-integer attractors in the single-hand repeated tapping of three-interval rhythms reported in the literature. The phase-attractive circle map has wider basins of attractions for such ratios. This work motivates the question whether CFC intrinsic to neural dynamics implements low-level priors for timing and coordination and thus becomes involved in phenomena as diverse as attractor states in bimanual coordination and the cross-cultural tendency for musical rhythms to have simple interval ratios. This article is part of the theme issue ‘Synchrony and rhythm interaction: from the brain to behavioural ecology’.

Sensitive detection of circular DNAs at single-nucleotide resolution using guided realignment of partially aligned reads

Background Circular DNA has recently been identified across different species including human normal and cancerous tissue, but short-read mappers are unable to align many of the reads crossing circle junctions hence limiting their detection from short-read sequencing data. Results Here, we propose a new method, Circle-Map that guides the realignment of partially aligned reads using information from discordantly mapped reads to map the short unaligned portions using a probabilistic model. We compared Circle-Map to similar up-to-date methods for circular DNA and RNA detection and we demonstrate how the approach implemented in Circle-Map dramatically increases sensitivity for detection of circular DNA on both simulated and real data while retaining high precision. Conclusion Circle-Map is an easy-to-use command line tool that implements the required pipeline to accurately detect circular DNA from circle enriched next generation sequencing experiments. Circle-Map is implemented in python3.6 and it is freely available at https://github.com/iprada/Circle-Map.