antilymphocyte serum
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2020 ◽  
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2019 ◽  
pp. 99-106
Author(s):  
M. Gauci ◽  
D.F. Bull ◽  
M. Schedlowski ◽  
A.J. Husband ◽  
M.G. King


Immunotherapy ◽  
2009 ◽  
Vol 1 (4) ◽  
pp. 585-598
Author(s):  
Maria Siemionow ◽  
Aleksandra Klimczak

The immunologic characteristics of composite tissue allografts (CTA), which contain skin, lymphoid elements and bone with bone marrow, raise new challenges for transplant immunologists. Owing to the heterogeneity of transplanted tissues in limb or face transplant models, researchers are focusing on the new tolerance-inducing strategies facilitating CTA acceptance. A number of immunosuppressive protocols have been designed to develop tolerance in experimental models; however, only a few protocols have been introduced to clinical transplantation. In this review, based on own experiences, we discuss the major strategies for tolerance induction in limb and face allograft models in experimental studies. This review is focused on tolerance induction strategies by establishment of donor-specific chimerism using different immunomodulatory protocols, including nonselective T-cell depletion with polyclonal antibody antilymphocyte serum and selective inhibition of αβ-T-cell receptors on the alloreactive T cells.



2008 ◽  
Vol 85 (9) ◽  
pp. 1246-1252 ◽  
Author(s):  
Xiaojuan Chen ◽  
Xiaomin Zhang ◽  
Courtney Larson ◽  
Guliang Xia ◽  
Dixon B. Kaufman


2006 ◽  
Vol 176 (7) ◽  
pp. 4125-4132 ◽  
Author(s):  
Keisuke Minamimura ◽  
Wenda Gao ◽  
Takashi Maki


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