Sēra dioksīda fizikāli ķīmisko īpašību pielietojums jaunu organiskās sintēzes metožu izstrādē / Development of New Organic Synthesis Methods Based on Physico-Chemical Properties of Sulfur Dioxide

The Doctoral Thesis has been prepared as a collection of thematically related scientific publications comprising five publications in the SCI journals, one patent of the Republic of Latvia, and one application for patent of the Republic of Latvia. We have carried out fundamental research on the applications of SO2 as a solvent and reagent in organic synthesis. We have developed several novel synthetic methods that represent the use of liquid SO2 as a solvent for chemical transformations that proceed via carbenium ion intermediates: a) hydration of aryl acetylenes; b) hydrohalogenation of aryl acetylenes; c) ring opening of methylenecyclopropanes with halides; d) glycosylation with glycosyl fluorides. By employing DABSO as an SO2 surrogate, we have also discovered the catalytic activity of Ru(II) complexes towards sulfonylative cross coupling reaction. This finding has been applied for the synthesis of sulfonyl derived compounds.

Multi-component Synthesis of Dihydro-1,3-azaborinine Derived Oxindole Isosteres

We report on the synthesis of the first examples of 1,3-BN oxindole derivatives, the BN-isosteres of the important compound class of the oxindoles. Hydroboration of terminal aryl acetylenes with FmesBH2...

An environmentally benign regioselective synthesis of 2-benzyl-4-arylquinoline derivatives using aryl amines, styrene oxides and aryl acetylenes

2-Benzyl-4-aryl/heteroaryl quinolines.

A single palladium site catalyst as a bridge for converting homogeneous to heterogeneous in dimerization of terminal aryl acetylenes

Herein, we utilize the surface dangling bond of MOFs as anchoring sites to access single Pd sites embedded on a hollow MOF nanobox.

Cu-Catalyzed electrophilic amination of internal alkynes via hydroalumination

A straightforward and efficient method for the synthesis of 1,2-diaryl-substituted enamines through the Cu-catalyzed electrophilic amination reaction of O-benzoyl hydroxylamines with vinylaluminum reagents generated in situ from the Ni-catalyzed hydroalumination of readily accessible internal aryl acetylenes is described.