rapid procedure
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2021 ◽  
Vol 12 ◽  
Author(s):  
Rongjun He ◽  
Stephanie A. Mowery ◽  
Joseph Chabenne ◽  
Brian Finan ◽  
John P. Mayer ◽  
...  

Optimization of peptides for therapeutic purposes often includes chemical conjugation or modification with substituents that serve to broaden pharmacology or improve pharmacokinetics. We report a convenient and rapid procedure for one-pot, site-specific conjugation of two cysteine-containing peptides that utilizes a bivalent linker comprising maleimide and iodoacetyl functional groups. Following maleimide-mediated peptide conjugation the linker was converted from an unstable thiosuccinimide to a stable thioether bond suitable for biological study by mild aqueous hydrolysis. The procedure is exemplified by peptide-peptide, peptide-small molecule, and peptide-fatty acid conjugations. The method provides a facile approach to search for enhanced biological outcomes through additive and sustained peptide pharmacology unencumbered by the prospect of chemical rearrangement in the course of biological study.


2021 ◽  
Vol Publish Ahead of Print ◽  
Author(s):  
Deniz Balci ◽  
Elvan Onur Kirimker ◽  
Meltem Bingol Kologlu ◽  
Evren Ustuner ◽  
Suheyla Karadag Erkoc ◽  
...  

2021 ◽  
Author(s):  
Qiaoying Chang ◽  
Lijuan Ge ◽  
Jian Li ◽  
Guoyu Qiu ◽  
Fuxiang Wu ◽  
...  

A rapid procedure for determination of 482 pesticide residues in Chinese Materia Medica by GC-Q-TOF/MS and LC-Q-TOF/MS (379 pesticides for LC, 327 pesticides for GC, and 226 pesticides for both)...


The Analyst ◽  
2021 ◽  
Author(s):  
Bo Sun ◽  
Weili Hong ◽  
Pu Wang ◽  
Guang-Hui Zheng ◽  
Xixiong Kang ◽  
...  

There is an urgent need to develop a rapid procedure that can rapidly identify and obtain antimicrobial susceptibility testing (AST) results directly from positive blood cultures. Here, we report a...


2020 ◽  
Vol Publish Ahead of Print ◽  
Author(s):  
Mosaad Abdel-Aziz ◽  
Nada M. Abdel-Aziz ◽  
Dina M. Abdel-Aziz ◽  
Noha Azab
Keyword(s):  

2020 ◽  
Vol 82 ◽  
pp. 93-96 ◽  
Author(s):  
Silvio Nadalin ◽  
Utz Settmacher ◽  
Falk Rauchfuß ◽  
Deniz Balci ◽  
Alfred Königsrainer ◽  
...  

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