alk protein
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2020 ◽  
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2020 ◽  
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Pathology ◽  
2019 ◽  
Vol 51 (6) ◽  
pp. 655-657 ◽  
Author(s):  
Jeremy Lewin ◽  
Jayesh Desai ◽  
Kortnye Smith ◽  
Stephen Luen ◽  
Daniel Wong


Author(s):  
N. A. Andreeva ◽  
A. E. Druy ◽  
T. V. Shamanskaya ◽  
D. Yu. Kachanov ◽  
S. R. Varfolomeeva

Neuroblastoma (NB) is the most common extracranial embryonic tumor in children with a variety of molecular biological and clinical characteristics. There is no single molecular genetic mechanism involved in the pathogenesis of NB, which determines its heterogeneity. Pathogenetically important event in the development of NB are aberrations of ALK gene (Anaplastic lymphoma kinase), which are found in 70 % of patients with familial form of NB and in 7– 10 % of patients with sporadic cases. ALK oncogene encodes a receptor of the same name, expressed on the membrane of cells of the central and peripheral nervous system, which is in the activated state in NB. The negative effect of ALK gene anomalies on the prognosis in patients with different risk groups of NB is described. ALK gene aberrations are more often detected duringrelapse and refractory course of the disease. Because of its tissue specificity, ALK protein is an ideal target for targeted therapy. This article presents a literature review of the role of ALK in NB.



2018 ◽  
Vol 36 (1) ◽  
pp. 1-6 ◽  
Author(s):  
Maria Łastowska ◽  
Joanna Trubicka ◽  
Agnieszka Karkucińska-Więckowska ◽  
Magdalena Kaleta ◽  
Magdalena Tarasińska ◽  
...  


2018 ◽  
Vol 10 (8) ◽  
pp. 4994-5009 ◽  
Author(s):  
Anna Grenda ◽  
Bożena Jarosz ◽  
Paweł Krawczyk ◽  
Tomasz Kucharczyk ◽  
Kamila Wojas-Krawczyk ◽  
...  


Oncotarget ◽  
2018 ◽  
Vol 9 (29) ◽  
pp. 20781-20794 ◽  
Author(s):  
Dina Mönch ◽  
Sabine Bode-Erdmann ◽  
Jörg Kalla ◽  
Jörn Sträter ◽  
Carsten Schwänen ◽  
...  


2018 ◽  
Vol 50 (2) ◽  
pp. 495-505 ◽  
Author(s):  
Ji Won Lee ◽  
Sung Hye Park ◽  
Hyoung Jin Kang ◽  
Kyung Duk Park ◽  
Hee Young Shin ◽  
...  


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