mixed adenoneuroendocrine carcinoma
Recently Published Documents


TOTAL DOCUMENTS

195
(FIVE YEARS 89)

H-INDEX

12
(FIVE YEARS 4)

Author(s):  
Zilong Zhang ◽  
Deyuan Zhong ◽  
Tianhang Feng ◽  
Yutong Yao ◽  
Xiaolun Huang

Medicine ◽  
2021 ◽  
Vol 100 (40) ◽  
pp. e27348
Author(s):  
Diogo J. Silva ◽  
Joana dos Santos ◽  
Ana Paula Vaz ◽  
Alexandra Mesquita

2021 ◽  
Vol 116 (1) ◽  
pp. S1249-S1249
Author(s):  
Michael Tran ◽  
John Green ◽  
Chad Spencer ◽  
Vindhya Bellamkonda ◽  
Pallavi Patil ◽  
...  

2021 ◽  
Vol 21 (1) ◽  
Author(s):  
Sishu Yang ◽  
Jiong Lu ◽  
Yulong Cai ◽  
Bei Li ◽  
Xianze Xiong

Abstract Background Mixed adenoneuroendocrine carcinoma is a rare clinical manifestation, especially in the gastric and ampullary. The purpose of this study was to investigate the clinicopathological features and prognosis of mixed adenoneuroendocrine carcinoma in the gastric and ampullary and summarize related treatment suggestions. Methods In all, 32 cases of mixed adenoneuroendocrine carcinoma in the gastric and ampullary that were diagnosed from resected specimens were analyzed from 2009 to 2015. The corresponding demographic, clinicopathological and survival data were retrospectively reviewed. Results The 1-year, 3-year and 5-year survival rates were 78.1%, 28.1 and 9.4%, respectively, and the median overall survival was 28.0 months. In all, 75.0% (24/32) had lymph node metastasis at the time of initial diagnosis. A multivariate analysis revealed that TNM stage (HR 6.444 95%CI 1.477–28.121 P = 0.013), lymph nodes metastasis (HR10.617 95%CI 1.409–79.997 P = 0.022), vascular invasion (HR 5.855 95%CI 1.719–19.940 P = 0.005), grade of the adenocarcinoma component (HR 3.876 95%CI 1.451–10.357 P = 0.007) and CD56 positivity (HR 0.265 95%CI 0.100–0.705 P = 0.008) were independent predictors of overall survival. Conclusions Mixed adenoneuroendocrine carcinoma is an aggressive clinical entity with a poor prognosis. Taking both the neuroendocrine component and the adenocarcinoma component into consideration of optimal treatment is strongly recommended.


Cureus ◽  
2021 ◽  
Author(s):  
Christopher Millet ◽  
Alisa Farokhian ◽  
Nader Mekheal ◽  
Balraj Singh ◽  
Walid Baddoura

Sign in / Sign up

Export Citation Format

Share Document