myosin isozymes
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2005 ◽  
Vol 122 (3) ◽  
pp. 527-533 ◽  
Author(s):  
Robert CARDINAUD
Keyword(s):  


1997 ◽  
Vol 137 (6) ◽  
pp. 1287-1307 ◽  
Author(s):  
Tama Hasson ◽  
Peter G. Gillespie ◽  
Jesus A. Garcia ◽  
Richard B. MacDonald ◽  
Yi-dong Zhao ◽  
...  

To understand how cells differentially use the dozens of myosin isozymes present in each genome, we examined the distribution of four unconventional myosin isozymes in the inner ear, a tissue that is particularly reliant on actin-rich structures and unconventional myosin isozymes. Of the four isozymes, each from a different class, three are expressed in the hair cells of amphibia and mammals. In stereocilia, constructed of cross-linked F-actin filaments, myosin-Iβ is found mostly near stereociliary tips, myosin-VI is largely absent, and myosin-VIIa colocalizes with crosslinks that connect adjacent stereocilia. In the cuticular plate, a meshwork of actin filaments, myosin-Iβ is excluded, myosin-VI is concentrated, and modest amounts of myosin-VIIa are present. These three myosin isozymes are excluded from other actin-rich domains, including the circumferential actin belt and the cortical actin network. A member of a fourth class, myosin-V, is not expressed in hair cells but is present at high levels in afferent nerve cells that innervate hair cells. Substantial amounts of myosins-Iβ, -VI, and -VIIa are located in a pericuticular necklace that is largely free of F-actin, squeezed between (but not associated with) actin of the cuticular plate and the circumferential belt. Our localization results suggest specific functions for three hair-cell myosin isozymes. As suggested previously, myosin-Iβ probably plays a role in adaptation; concentration of myosin-VI in cuticular plates and association with stereociliary rootlets suggest that this isozyme participates in rigidly anchoring stereocilia; and finally, colocalization with cross-links between adjacent stereocilia indicates that myosin-VIIa is required for the structural integrity of hair bundles.



1995 ◽  
Vol 1231 (1) ◽  
pp. 69-75 ◽  
Author(s):  
Seiryo Sugiura ◽  
Hiroshi Yamashita ◽  
Masataka Sata ◽  
Shin-ichi Momomura ◽  
Takashi Serizawa ◽  
...  


1994 ◽  
Vol 132 (1) ◽  
pp. 69-80 ◽  
Author(s):  
Heinz Rupp ◽  
Vijayan Elimban ◽  
Naranjan S. Dhalla


1993 ◽  
Vol 27 (10) ◽  
pp. 1869-1872 ◽  
Author(s):  
V. Raizada ◽  
D. Pathak ◽  
T. M Blomquist ◽  
R. Minser ◽  
B. Woodfin




1992 ◽  
Vol 24 ◽  
pp. 155
Author(s):  
Masataka Sata ◽  
Hiroshi Yamashita ◽  
Seiryo Sugiura ◽  
Takashi Serizawa


1991 ◽  
Vol 68 (6) ◽  
pp. 1582-1590 ◽  
Author(s):  
N S Kato ◽  
A Weisberg ◽  
S Winegrad


1990 ◽  
Vol 96 (1) ◽  
pp. 79-88 ◽  
Author(s):  
Adawia A. Alousi ◽  
Alison M. Grant ◽  
John R. Etzler ◽  
Barry R. Cofer ◽  
Joanna Van der Bel-Kahn ◽  
...  


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