A brief history of the Centre for Mathematical and Statistical Sciences, Kerala, India, is given and an overview of Mathai’s research and education programs in the following topics is outlined: Fractional Calculus; Functions of Matrix Argument—M-transforms, M-convolutions; Krätzel integrals; Pathway Models; Geometrical Probabilities; Astrophysics—reaction rate theory, solar neutrinos; Special Functions—G and H-functions; Multivariate Analysis; Algorithms for Non-linear Least Squares; Characterizations—characterizations of densities, information measure, axiomatic definitions, pseudo analytic functions of matrix argument and characterization of the normal probability law; Mathai’s Entropy—entropy optimization; Analysis of Variance; Population Problems and Social Sciences; Quadratic and Bilinear Forms; Linear Algebra; Probability and Statistics.