Abstract 17963: Cardioprotective Effects of Ecklonia Cava Polyphenol on Doxorubicin-induced Cardiomyopathy in Rats

Introduction: Long-term therapy with doxorubicin is associated with a high incidence of a cumulative and irreversible dilated cardiomyopathy, despite of its broad anti-neoplastic effectiveness. The goal of this study was to evaluate the cardioprotective effects and safety of seapolyphenol (polyphenol purified from Ecklonia cava) against doxorubicin-induced cardiotoxicity in an animal rat model. Methods and Results: In total 28 rats including doxorubicin and control groups, baseline and 6 weeks follow up echocardiography were practiced. Left ventricular ejection fraction significantly decreased and the left ventricular end diastolic/systolic dimension and LV mass index significantly increased in single doxorubicin group compared to high dose seapolynol plus doxorubicin group. Also, electron microscopic finding showed less impaired myofiber and mitochondria in high dose seapolynol plus doxorubicin group than in single doxorubicin group. Conclusions: Our data showed that high dose seapolynol had cardioprotective effects against doxorubicin-induced cardiotoxicity in an animal rat model with the evidence of electron microscopic finding in addition to echocardiographic results..