Heterotopic Adipose Tissue in the Placental Parenchyma: Case Report

Objective: Reports of heterotopic tissue in the placenta are few and mainly include liver and adrenal cells. We report on adipose tissue found in the placenta. Case report: We present the case of a microscopic finding in a 25-year-old’s placenta who suffered from hypertensive disorder in pregnancy. During routine microscopic study, we observed a heterotopic, benign, circumscribed and intervillous nodule of adipose tissue. Conclusion: To our knowledge, there is no other reported case of adipocytes among chorionic villi. Why foreign tissues show up in the placenta remains unknown; however, several new theories offer explanations.

Abstract 17963: Cardioprotective Effects of Ecklonia Cava Polyphenol on Doxorubicin-induced Cardiomyopathy in Rats

Introduction: Long-term therapy with doxorubicin is associated with a high incidence of a cumulative and irreversible dilated cardiomyopathy, despite of its broad anti-neoplastic effectiveness. The goal of this study was to evaluate the cardioprotective effects and safety of seapolyphenol (polyphenol purified from Ecklonia cava) against doxorubicin-induced cardiotoxicity in an animal rat model. Methods and Results: In total 28 rats including doxorubicin and control groups, baseline and 6 weeks follow up echocardiography were practiced. Left ventricular ejection fraction significantly decreased and the left ventricular end diastolic/systolic dimension and LV mass index significantly increased in single doxorubicin group compared to high dose seapolynol plus doxorubicin group. Also, electron microscopic finding showed less impaired myofiber and mitochondria in high dose seapolynol plus doxorubicin group than in single doxorubicin group. Conclusions: Our data showed that high dose seapolynol had cardioprotective effects against doxorubicin-induced cardiotoxicity in an animal rat model with the evidence of electron microscopic finding in addition to echocardiographic results..