respiratory airway
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2021 ◽  
Vol 27 (3) ◽  
pp. 111-120
Author(s):  
Ji-Woo Jung ◽  
Eung-Sam Kim


2021 ◽  
Author(s):  
Yaling Zhang ◽  
Dingailu Ma ◽  
Jitao David Zhang ◽  
Xinan Liu ◽  
Qihui Zhu ◽  
...  

SARS-CoV-2 and its induced COVID-19 remains as a global health calamity. Severe symptoms and high mortality, caused by cytokine storm and acute respiratory distress syndrome in the lower respiratory airway, are always associated with elderly individuals and those with comorbidities; whereas mild or moderate COVID-19 patients have limited upper respiratory flu-like symptoms. There is an urgent need to investigate SARS-CoV-2 and other coronaviruses replication and immune responses in human respiratory systems. The human reconstituted airway epithelial air-liquid interface (ALI) models are the most physiologically relevant model for the investigation of coronavirus infection and virus-triggered innate immune signatures. We established ALI models representing both the upper and the lower respiratory airway to characterize the coronavirus infection kinetics, tissue pathophysiology, and innate immune signatures from upper and lower respiratory tract perspective. Our data suggested these in vitro ALI models maintain high physiological relevance with human airway tissues. The coronavirus induced immune response observed in these upper and lower respiratory airway models are similar to what has been reported in COVID-19 patients. The antiviral efficacy results of a few promising anti-coronavirus drugs in these models were consistent with previous reports and could be valuable for the human dose prediction. Taken together, our study demonstrates the importance of 3D airway epithelial ALI model for the understanding of coronavirus pathogenesis and the discovery and development of anti-coronavirus drugs.



2021 ◽  
Vol 1104 (1) ◽  
pp. 012022
Author(s):  
Rakesh Kumar Shukla ◽  
Sandeep Tiwari ◽  
Ashutosh Kumar


2020 ◽  
Vol 38 (8) ◽  
pp. 1698.e1-1698.e4
Author(s):  
Yichun Jiang ◽  
Jun Chen ◽  
Fulan Cen ◽  
Xu Li ◽  
Zhi Song ◽  
...  


2020 ◽  
Vol 145 ◽  
pp. 105233 ◽  
Author(s):  
Kaveh Ahookhosh ◽  
Oveis Pourmehran ◽  
Habib Aminfar ◽  
Mousa Mohammadpourfard ◽  
Mohammad Mohsen Sarafraz ◽  
...  
Keyword(s):  


Author(s):  
Ryosuke Machida ◽  
Syuhei Nozawa ◽  
Kazuhisa Urushihata ◽  
Atsuhito Ushiki ◽  
Masanori Yasuo ◽  
...  
Keyword(s):  


2019 ◽  
Vol 566 ◽  
pp. 157-172 ◽  
Author(s):  
Kaveh Ahookhosh ◽  
Shadi Yaqoubi ◽  
Mousa Mohammadpourfard ◽  
Hamed Hamishehkar ◽  
Habib Aminfar


2019 ◽  
Vol 10 ◽  
Author(s):  
Yaneisi Vázquez ◽  
Liliana González ◽  
Loreani Noguera ◽  
Pablo A. González ◽  
Claudia A. Riedel ◽  
...  


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