Curvature and Entropy Statistics-Based Blind Multi-Exposure Fusion Image Quality Assessment

The multi-exposure fusion (MEF) technique provides humans a new opportunity for natural scene representation, and the related quality assessment issues are urgent to be considered for validating the effectiveness of these techniques. In this paper, a curvature and entropy statistics-based blind MEF image quality assessment (CE-BMIQA) method is proposed to perceive the quality degradation objectively. The transformation process from multiple images with different exposure levels to the final MEF image leads to the loss of structure and detail information, so that the related curvature statistics features and entropy statistics features are utilized to portray the above distortion presentation. The former features are extracted from the histogram statistics of surface type map calculated by mean curvature and Gaussian curvature of MEF image. Moreover, contrast energy weighting is attached to consider the contrast variation of the MEF image. The latter features refer to spatial entropy and spectral entropy. All extracted features based on a multi-scale scheme are aggregated by training the quality regression model via random forest. Since the MEF image and its feature representation are spatially symmetric in physics, the final prediction quality is symmetric to and representative of the image distortion. Experimental results on a public MEF image database demonstrate that the proposed CE-BMIQA method achieves more outstanding performance than the state-of-the-art blind image quality assessment ones.

OR02-02 Possible Age and Time-Of-Day Differences in the Hypothalamo-Pituitary-Testicular, and Adrenal, Response to Total Overnight Sleep Restriction

Introduction: In young men, sleep restriction decreases testosterone and increases afternoon cortisol, leading to anabolic-catabolic imbalance, insulin resistance and metabolic, neurocognitive, reproductive, and other adverse effects. Age-related differences in the hypothalamo-pituitary-testicular/adrenal response to sleep restriction could expose older individuals to greater or lesser risk, but this possibility has not been previously studied. Subjects and Methods: Thirty-five healthy young and older men aged 18-30y (n=17) and 60-80y (n=18), underwent blood sampling in the Mayo Clinic Center for Clinical and Translational Science every 10 minutes for 24 hours from 6PM-6PM under two conditions in random order spaced at least 3 weeks apart: awake (no sleep) or sleep (from 10PM to 6AM). Blood was assayed for LH, testosterone (T) and cortisol (F), and then analyzed by automated mathematical deconvolution and with cross approximate entropy statistics to determine hormone secretion and hormone synchrony, respectively. Statistical significance was construed by repeated measures ANOVA using a full factorial model that included age, sleep and the interaction. Results: Sleep deprivation had multiple effects on 24-hour (6PM-6PM) Te secretion with significant reductions in mean concentrations, basal, total and pulsatile secretion, and pulse frequency (each P<0.05), in the absence of detectable changes in LH. These effects were most apparent in older men and differed according to age for some parameters: pulsatile Te secretion (P=0.03) and T pulse frequency (P=0.02). Time-of-day analyses revealed that sleep restriction significantly reduced Te in the morning (6AM-9AM) and afternoon (3PM-6PM), reduced LH in the morning, and increased F in the afternoon, particularly in older men. Cross-approximate entropy statistics showed that sleep restriction enforced greater LH-Te and Te-LH joint synchrony in the morning (P<0.05 for each), but not in the afternoon. Conclusion: Sleep restriction decreases morning LH secretion, morning and afternoon Te secretion, and increases afternoon F secretion, especially in older men. This combination of findings could plausibly cause metabolic and reproductive ill-health when accumulated over decades of life, and may explain how chronic sleep loss contributes to metabolic and reproductive diseases that are more prevalent in older men. These preliminary data also suggest a time-of-day dependent uncoupling of the regulatory control of the testicular axis, and of cortisol secretion. Direct verification by interventions that manipulate hormones during the morning and late afternoon in appropriately matched cohorts of young and older men are now required.