The purpose of this study was to determine how personality characteristics, sense of organizational empowerment, and job satisfaction combine to predict turnover intention among a population of Sexual Assault Nurse Examiner (SANE) nurses. Data were collected from 161 SANE nurses from 23 SANE organizations across the central and west United States through standardized tools and a demographic questionnaire. Both personality, namely agreeableness, and workplace characteristics, particularly perceived empowerment and job satisfaction, combine to predict intention to leave the job of these sampled SANE nurses. One particularly curious finding is the positive prediction of agreeableness on turnover intention – that is, the more agreeable people would be more likely to leave their jobs as SANE nurses. Professionals can gain insight from the path analysis results that show the need to address both personal and organizational factors in mitigating turnover intention among SANE nurses. This appears to be particularly true in providing a sense of empowerment and opportunity within the organization.