The article analyzes the US’s security relations with Africa, including the “war on terror”, as well as the role of the US African Military Command (AFRICOM) in resolving regional conflicts. After the end of the Cold War and a failed mission in Somalia, the United States ended major military operations in Africa. However, in the past few years, the strategic interests of the United States in the region have increased due to the threats of the activities of international terrorist groups. The article reveals the goals of Presidents George Bush, Jr., Barack Obama, and Donald Trump in relation to Africa in the context of regional security challenges and the main results of US foreign policy under three administrations.