The extraordinary role of Isaiah in Christian art and music, from the ox and the ass on ancient catacombs to Handel’s Messiah, is well known, but there are also significant portrayals of him and his prophecies in Jewish art and music, as well as a few striking illustrations of episodes in his life in Islamic art. This chapter looks first at examples of how the call of the prophet, Sennacherib’s siege of Jerusalem, his martyrdom, and other scenes from his life have been depicted in the art of all three religious traditions, and then Christian portrayals of the Annunciation, the Nativity, the Fall of idols in Egypt, the Passion, and the Winepress with texts from Isaiah, as well as world peace and the peaceable kingdom. Musical settings of texts from Isaiah range from Veni Immanuel, the Rorate, Mendelssohn’s Elijah, and Brahms German Requiem, to modern Jewish celebrations of the establishment of the State of Israel in 1948 and popular Hebrew songs like “Mayim be-sason” (12:3) and “Yerushalayim shel zahab.”