A Novel Hybrid Microdosimeter for Radiation Field Characterization Based on the Tissue Equivalent Proportional Counter Detector and Low Gain Avalanche Detectors Tracker: A Feasibility Study

In microdosimetry, lineal energies y are calculated from energy depositions ϵ inside the microdosimeter divided by the mean chord length, whose value is based on geometrical assumptions on both the detector and the radiation field. This work presents an innovative two-stages hybrid detector (HDM: hybrid detector for microdosimetry) composed by a tissue equivalent proportional counter and a silicon tracker made of 4 low gain avalanche diode. This design provides a direct measurement of energy deposition in tissue as well as particles tracking with a submillimeter lateral spatial resolution. The data collected by the detector allow to obtain the real track length traversed by each particle in the tissue equivalent proportional counter and thus estimates microdosimetry spectra without the mean chord length approximation. Using Geant4 toolkit, we investigated HDM performances in terms of detection and tracking efficiencies when placed in water and exposed to protons and carbon ions in the therapeutic energy range. The results indicate that the mean chord length approximation underestimate particles with short track, which often are characterized by a high energy deposition and thus can be biologically relevant. Tracking efficiency depends on the low gain avalanche diode configurations: 34 strips sensors have a higher detection efficiency but lower spatial resolution than 71 strips sensors. Further studies will be performed both with Geant4 and experimentally to optimize the detector design on the bases of the radiation field of interest.The main purpose of HDM is to improve the assessment of the radiation biological effectiveness via microdosimetric measurements, exploiting a new definition of the lineal energy (yT), defined as the energy deposition ϵ inside the microdosimeter divided by the real track length of the particle.

APPLICABILITY OF PURE PROPANE GAS FOR MICRODOSIMETRY AT BRACHYTHERAPY ENERGIES: A FLUKA STUDY

Applicability of pure propane gas for microdosimetric measurements at photon energies relevant in brachytherapy is studied using the Monte Carlo-based FLUKA code. Monoenergetic photons in the energy range of 20–1250 keV and brachytherapy sources such as 103Pd, 125I, 169Yb, 192Ir, 137Cs and 60Co are considered in the study. Using the calculated values of energy deposited in the sensitive region of LET-1/2 tissue-equivalent proportional counter filled with pure propane gas and tissue-equivalent propane gas, values of density scaling factor for the site sizes of 1 and 8 μm are obtained. The study shows that density of propane gas should be lowered by a factor of about 0.93 for 169Yb, 192Ir, 137Cs and 60Co sources for the site sizes of 1–8 μm. For 125I source, the density of propane gas requires a scaling of 0.93 for 1 μm site size, whereas for site sizes 2–8 μm, density need not be altered. 103Pd source does not require density scaling for site sizes 1–8 μm.

Measurement System Design of Micro-Dose Experimental Spectrum

Tissue equivalent proportional counter (TEPC) is used to measure the micro-dose spectrum of ionizing radiation. Through changing tissue-equivalent gas pressure, TEPC can simulate the case of radiation energy deposition in different sizes of human cells. Various dosimetric quantities can be obtained such as absorbed dose, radiation quality factor and micro-dose equivalent. Because TEPC simulated cell size is less than the range of ionizing radiation particles, TEPC can be used as linear energy transfer spectroscopy, which can identify different linear energy transfer particles in a mixed radiation field and play an important role in mixed neutron–photon radiation field monitoring and protection. A tissue equivalent proportional counter is designed and manufactured in this paper. Through the built of micro-dose detector signal testing platform, and the realization of measurement of micro-dose detector signal debugging and important parameters (stability, energy resolution, etc.) by [Formula: see text] source method, micro-dose energy spectrum analysis and experimental measurements of Cf-252 source were ultimately achieved. Results show that the detector has good sealing performance and stability, with 12 h stability better than 2.7%. Based on all the above spectra, micro-dosing spectrum of Cf-252 source was experimentally obtained.

THE DETERMINATION OF NEUTRON FLUENCE TO ABSORBED DOSE CONVERSION COEFFICIENTS AND RELATIVE BIOLOGICAL EFFECT BASED ON MICRODOSIMETRY MEASUREMENTS

A tissue-equivalent proportional counter (TEPC) is a reference detector to measure microdosimetric quantities. A conventional spherical TEPC and a novel TEPC based on a ceramic thick gas electron multiplier (THGEM) foil were developed to carry out microdosimetric measurements of lineal energy spectra in monoenergetic and 252Cf/241Am-Be neutron radiation fields, and the absorbed dose values had been derived. In order to go further in radiobiology and therapy, the fluence to absorbed dose conversion coefficients in neutron fields were also determined. According to the dose distribution in lineal energy, the neutron relative biological effect (RBE) values were also calculated using an empirical procedure applying biological weighting functions.

MONTE CARLO-BASED INVESTIGATION OF MICRODOSIMETRIC DISTRIBUTION OF HIGH ENERGY BRACHYTHERAPY SOURCES

FLUKA-based Monte Carlo calculations were carried out to study microdosimetric distributions in air and in water for encapsulated high energy brachytherapy sources (60Co, 137Cs, 192Ir and 169Yb) by simulating a Tissue Equivalent Proportional Counter (Model LET1/2) having sensitive diameter of 1. 27 cm for a site size of 1 μm. The study also included microdosimetric distributions of bare sources. When the sources are in air, for a given source, the source geometry does not affect the y¯F and y¯D values significantly. When the encapsulated 192Ir, 137Cs and 60Co sources are in water, y¯F and y¯D values increase with distance in water which is due to degradation in the energy of photons. Using the calculated values of y¯D, relative biological effectiveness (RBE) was obtained for the investigated sources. When 60Co, 137Cs and 192Ir sources are in water, RBE increases from 1.03 ± 0.01 to 1.17 ± 0.01, 1.24 ± 0.01 to 1.46 ± 0.02 and 1.50 ± 0.01 to 1.75 ± 0.03, respectively, when the distance was increased from 3–15 cm, whereas for 169Yb, RBE is about 2, independent of distance in water.