Abstract 14407: Effect of Initial Defibrillation on Chest Compression Artifact in the ECG

Introduction: Chest compressions (CCs) during CPR cause electrical artifacts in the ECG. Prior work has found that the severity of CC artifact, quantified by the signal-to-noise ratio (SNR), affects the diagnostic sensitivity of defibrillator algorithms designed to detect shockable rhythms during CCs. Whether SNR is altered by defibrillation is unknown. We therefore compared SNR before and after defibrillation shocks. Methods: We evaluated patients with out-of-hospital cardiac arrest who received at least 1 defibrillation shock, had subsequent ventricular fibrillation (VF), and had a calculable SNR before and after initial shock. We measured the CC artifact during VF before and after the initial shock (and up to 3 subsequent shocks) using CC amplitude and SNR. CC amplitude was defined as the median peak-to-peak voltage of the ECG during CCs. SNR was calculated as the log ratio of the power of the CC-free VF signal to the power of the estimated noise caused by CC artifact (Figure). Differences in medians before and after the first 4 shocks were evaluated using Wilcoxon signed-rank test with Bonferroni correction (alpha = 0.0125). Results: A total of 192 patients had a calculable SNR during VF before and after initial shock. Of these, the median CC amplitude decreased after the initial shock (0.93 vs. 0.75 mV, p<0.001), and SNR improved (-2.30 vs. -1.07 dB, p=0.004). In contrast to the initial shock, both CC amplitude and SNR did not differ significantly before and after shock 2 (n=107), shock 3 (n=54), or shock 4 (n=32). Conclusion: Measures of CC artifact in the ECG were greater before initial shock than afterward. This could potentially be due to changes in CC characteristics, variations in physical perturbation of the defibrillator electrodes, degradation of VF over time, or effects of tissue electroporation on paddle conductivity and noise. These findings may have implications for selection of decision thresholds in algorithms to detect shockable rhythm during CCs.