Equivalent Method Development and Cross Validation of Pharmacopoeial Method of Montelukast Sodium

The purpose of this exploration research work article is to develop equivalent method and evaluate its equivalency (Cross validation) against pharmacopoeial method of Montelukast sodium for the evaluation and assessment of process related impurities i.e. Methyl MLK impurity in Montelukast sodium by HPLC method and its principles. The method mentioned in European Pharmacopoeia (EP) and United States Pharmacopoeia (USP) does not sufficiently separates impurity C and impurity D , as these impurities elutes under the main peak and the pharmacopoeial methods were also not able to detect the Methyl MLK impurity which is not listed in USP monograph. So our prime design of experiment is to develop of new high-performance liquid chromatographic (HPLC) method which eliminates the drawback of two pharmacopoeial methods and this proposed created strategy is fit for recognition and detection of Methyl MLK impurity and separation of all process related impurities of Montelukast sodium mentioned in EP and USP monographs. An efficient strategy screening and scouting in which various C-18 columns were tried and tested. LUNA C-18 column utilized in RP HPLC mode ended up being the phenomenal decision for the technique streamlining. The proportion of acetonitrile and trifluoroacetic acid (TFA) in water and in the mobile phase, column temperature, flow rate and diluents were considered as basic strategy boundary. The method developed equivalency was checked in terms of Specificity, LOD, Quantitation (LOQ), Precision, Linearity, Relative response factor (RRF), and Accuracy.

EVALUATION OF CAPTURING ARCHITECTURALLY SIGNIFICANT REQUIREMENTS

Every software development organization strives for customer satisfaction. It is universally accepted that the success of software development lies in the clear understanding of the client requirements. During requirement elicitation and analysis stage, the system analyst identifies the functional and non-functional requirements from the customer. Security, usability, reliability, performance, scalability and supportability are the significant quality attributes of a software system. These quality attributes are also referred as non-functional requirements. Only a few functional and quality attributes requirement help to identify and shape the software architecture. A software system’s architecture is the set of prime design decisions made about the system. If the requirement influences the architectural design decision then, it is referred as Architecturally Significant Requirement (ASR). Identifying and specifying all the possible ASR are important tasks in the requirement elicitation and analysis stage.In this research, general problems that are faced while capturing and specifying ASR in requirement elicitation and analysis is studied. Among the different requirement elicitation techniques, use case diagram has been identified and enhanced to solve the problem of capturing and specifying ASR during the requirement elicitation and analysis phase

Underwater explosion approximate method research on ship with polymer coating

Battle damage survivability is the prime design criterion of naval ships. Composites and hybrid structures such as polymer coating attract much attention to increase the ship survivability. Aiming to develop the parameter optimization design of the coating and to assess the underwater explosion shock environment and the blast-resistant effect of polymer coating efficiently, an approximate numerical method was performed in this preliminary study. An equivalent continuum model based on the homogenization theory was introduced to simulate the dynamic behavior of the coating. The test data of full-scale underwater explosion tests and the numerical simulation results were investigated. The blast-resistant property of the polymer coating was elaborated. The core strength had an important influence on the ship dynamic response: under low-intensity underwater explosion shock load, “soft” core had greater blast-resistant effect than the other ones, while under high-intensity underwater explosion shock load, “ordinary” core and “hard” core had better blast-resistant effect than the “soft” core.

A study of slip factor and velocity components at the rotor exit of forward-curved squirrel cage fans, using laser Doppler anemometry

Velocity profiles outside the rotor of four squirrel cage fans are measured in order to calculate their local slip factors. They show that the fluid exit angle from the rotor and the blade outlet angle of such fans are very different. Inlet configuration and volute spread angle both affected the direction of the flow out of the rotor and hence the slip factor. The general understanding in centrifugal turbomachines is that more energy transfer per unit mass is equivalent to a larger tangential component of velocity and therefore a larger slip factor. In squirrel cage fans a small slip factor results from a large radial velocity component out of the rotor. This gives a larger volumetric flowrate with no sensible head loss. The advantages of a large incidence angle and a large deviation mean that flow adherence to the blades is not always a prime design criterion in such fans.