The dynamics of water quality along the Northern Dvina River is considered within the context of anthropogenic impact. In general, the waters of the river are characterized as very polluted. Cases of high and extremely high levels of water pollution in various locations have been considered. Organic substances, iron compounds, copper, and zinc are relatively common pollutants. Long-term average volumes of inflow of certain pollutants along the length of the river exceed the maximum permissible concentration by 2 to 5 times. A tendency toward slightly improved water quality downstream with decreasing amounts of petroleum products and zinc compounds was revealed also.