ionic lanthanum
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1992 ◽  
Vol 56 (9) ◽  
pp. 911-920 ◽  
Author(s):  
FUMIHIRO TANNO ◽  
KAZUHIDE AKIYAMA ◽  
EIICHI GESHI ◽  
TOSHIKUNI YANAGISHITA ◽  
NOBURU KONNO ◽  
...  


Neuroreport ◽  
1992 ◽  
Vol 3 (1) ◽  
pp. 101-104 ◽  
Author(s):  
Spencer D. Provan ◽  
Michael D. Miyamoto


1989 ◽  
Vol 180 (3) ◽  
pp. 237-242 ◽  
Author(s):  
M. N. Ghabriel ◽  
K. H. Jennings ◽  
G. Allt




1987 ◽  
Vol 21 (8) ◽  
pp. 569-575 ◽  
Author(s):  
S. A BARMAN ◽  
M. D OLSON ◽  
J. T SAARI


1983 ◽  
Vol 60 (1-2) ◽  
pp. 49-60 ◽  
Author(s):  
K. Dorovini-Zis ◽  
M. Sato ◽  
G. Goping ◽  
S. Rapoport ◽  
M. Brightman


1982 ◽  
Vol 242 (5) ◽  
pp. C388-C392 ◽  
Author(s):  
J. N. Forrest ◽  
J. L. Boyer ◽  
T. A. Ardito ◽  
H. V. Murdaugh ◽  
J. B. Wade

In epithelia that secrete sodium chloride, high-conductance tight junctions between cells have been proposed as the primary pathway for transepithelial sodium flux. We examined the properties of tight junctions in the perfused rectal gland of the dogfish shark during basal secretion and following adenosine 3',5'-cyclic monophosphate stimulation of sodium chloride secretion. Freeze-fracture electron microscopy revealed extensive interdigitation of adjacent cells with an associated amplification in the length of tight junctions per area of luminal surface, averaging 102 +/- 4.7 m/cm2 in outer regions of 80 +/- 6.7 in inner regions of the gland. Marked heterogeneity of junctional structure was present with junctional elements varying from single strands to three duplex elements and junctional depth varying from 15 to 60 nm. In glands perfused with lanthanum chloride, ionic lanthanum filled the intercellular space up to but not through the tight junctions. Characteristics of tight junctions were not different during basal and maximally stimulated sodium chloride secretion. These studies define tight junctions in the rectal gland as an anatomical barrier capable of restricting the passage of relatively small molecules such as urea while providing a greatly amplified junctional area for the passive diffusion of sodium and water.



1982 ◽  
Vol 242 (4) ◽  
pp. G319-G325 ◽  
Author(s):  
J. S. Reed ◽  
N. D. Smith ◽  
J. L. Boyer

In the isolated perfused liver of the little skate, Raja erinacea, bile flow averaged 5.07 +/- 0.58 (mean +/- SE) microliters.h-1.g liver-1 in 21 experiments at a perfusion pressure of 5.0 cm Ringer compared to 3.79 +/- 0.32 in 38 experiments at 2.5 cm (P less than 0.05). [14C]inulin readily entered skate bile. Bile-to-plasma [14C]inulin ratios corrected for delay in transit time, averaged 0.46 +/- 0.07 at 1 h and rose to 0.74 +/- 0.06 by 4 h, although bile flow remained constant. In experiments in which [14C]inulin reached equilibrium between bile and plasma, the bile-to-plasma ratio conformed to the theoretical relationship between bile flow, solvent drag, and inert solute diffusion predicted at extremely low bile flows, but demonstrated that the skate biliary tree is more permeable to inulin than that of the rat. Electron microscopic studies demonstrated that ionic lanthanum could traverse the tight junctions. However, freeze-fracture studies of junction structure did not differ qualitatively from similar studies in the rat. Partial dependence of bile flow on perfusion pressure, high bile-to-plasma inulin ratios, and permeability of the canalicular tight junctions to ionic lanthanum all suggest that the paracellular pathway may be an important component of bile formation in the skate.



1981 ◽  
Vol 374 (1 Vestibular an) ◽  
pp. 11-19 ◽  
Author(s):  
Helge Rask-Andersen ◽  
Göran Bredberg ◽  
Leif Lyttkens ◽  
Göran Lööf


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