Degradative Studies in the Picrotoxinin Series

<p>PICROTOXIN is a bitter principle of the berries of the species Mensiperum coculus and Anamirata coculus, creepers which are indigenous to the East Indies. It was first isolated in 1812, and subsequent elementary analysis showed that it contained only carbon, hydrogen, and oxygen. Because of its potent poisonous nature and its physiological action, together with its high oxygen content, picrotoxin has often been referred to as an “oxygen alkaloid”. It is a central nervous system stimulant and a powerful convulsant drug. It is used in medicine as an antidote to barbiturate poisoning, being still preferred for this purpose over many other drugs. It has also been used in cases of alcoholic intoxication, and as a fish poison.</p>

Degradative Studies in the Picrotoxinin Series

<p>PICROTOXIN is a bitter principle of the berries of the species Mensiperum coculus and Anamirata coculus, creepers which are indigenous to the East Indies. It was first isolated in 1812, and subsequent elementary analysis showed that it contained only carbon, hydrogen, and oxygen. Because of its potent poisonous nature and its physiological action, together with its high oxygen content, picrotoxin has often been referred to as an “oxygen alkaloid”. It is a central nervous system stimulant and a powerful convulsant drug. It is used in medicine as an antidote to barbiturate poisoning, being still preferred for this purpose over many other drugs. It has also been used in cases of alcoholic intoxication, and as a fish poison.</p>

Toxicology

Poisons: general principles 180 Diagnosis of poisoning 182 Poisons: supportive care 183 Reducing absorption of poison 184 Antidotes for poisons 186 Opioid poisoning 188 Salicylate poisoning 189 Paracetamol poisoning 190 Tricyclic antidepressant poisoning 194 Benzodiazepine poisoning 196 Clomethiazole poisoning 196 Phenothiazine poisoning 196 Barbiturate poisoning ...