Degradative Studies in the Picrotoxinin Series

<p>PICROTOXIN is a bitter principle of the berries of the species Mensiperum coculus and Anamirata coculus, creepers which are indigenous to the East Indies. It was first isolated in 1812, and subsequent elementary analysis showed that it contained only carbon, hydrogen, and oxygen. Because of its potent poisonous nature and its physiological action, together with its high oxygen content, picrotoxin has often been referred to as an “oxygen alkaloid”. It is a central nervous system stimulant and a powerful convulsant drug. It is used in medicine as an antidote to barbiturate poisoning, being still preferred for this purpose over many other drugs. It has also been used in cases of alcoholic intoxication, and as a fish poison.</p>

Degradative Studies in the Picrotoxinin Series

<p>PICROTOXIN is a bitter principle of the berries of the species Mensiperum coculus and Anamirata coculus, creepers which are indigenous to the East Indies. It was first isolated in 1812, and subsequent elementary analysis showed that it contained only carbon, hydrogen, and oxygen. Because of its potent poisonous nature and its physiological action, together with its high oxygen content, picrotoxin has often been referred to as an “oxygen alkaloid”. It is a central nervous system stimulant and a powerful convulsant drug. It is used in medicine as an antidote to barbiturate poisoning, being still preferred for this purpose over many other drugs. It has also been used in cases of alcoholic intoxication, and as a fish poison.</p>

Fetal Valproate Syndrome – A Case Report

Background: Fetal Valproate Syndrome (FVS) results from prenatal exposure to valproic acid (VPA). Case characteristics: A four year old female child presented with facial dysmorphism and features of autism spectrum disorder (ASD). She had in-utero exposure to valproic acid (VPA). Message: VPA to be avoided in pregnancy and in Dysmorphism or ASD children maternal anti- convulsant drug history must be taken.

A Mechanistic Studies of Mn(II) Catalyzed Oxidation of a Gabapentin by Peroxomonosulphate in Aqueous Alkaline Medium

A mechanistic approach to the influence of Mn(II) catalyzed oxidative deamination of an anti-convulsant drug [GP] by peroxomonosulphate (PMS) at a constant ionic strength of 1.0 mol dm

Sturge-Weber syndrome-A Case report

Sturge-weber syndrome is a disease characterized by capillary or cavernous haemangionsm (Port-wine stain) along the cutaneous division of Trigennial nerve. There is venous haemangionsm in subjacent leptomeninges, which may spread causing atrophy of cortex. The patient Md. Zobair Hossain, 11 years old boy, nondiabetic, nonhypertensive presented to us on 20.05.2011 with the complaints of repeated bleeding from a swelling over the outer aspect of right eye ball for 1 month, weakness of left half of body for 1 year and repeated convulsion for 7 years. Diagnosis was confirmed vy CT scan of brain. Through treatment is unsatisfactory, he was advised for laser theraphy for coetaneous lesion and anti-convulsant drug epilepsy. DOI: http://dx.doi.org/10.3329/fmcj.v8i1.16899 Faridpur Med. Coll. J. 2013;8(1): 44-45