hepatic imaging
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Author(s):  
Karl Julius Thrane ◽  
Lil Sofie Ording Müller ◽  
Kathrine Rydén Suther ◽  
Kristian Stien Thomassen ◽  
Henrik Holmström ◽  
...  

Abstract Purpose Patients with Fontan circulation are at risk of developing hepatic fibrosis/cirrhosis. The mechanisms and disease development are unclear and early secondary liver cancer is a concern. This study will describe hepatic imaging findings in a national cohort of adolescents with Fontan circulation. Methods The patients prospectively underwent abdominal contrast enhanced magnetic resonance imaging (MRI) including diffusion-weighted imaging. Images were assessed for criteria of fibrosis/cirrhosis including characterization of hepatic nodules. These nodules were in addition, assessed by ultrasonography (US). Nodules ≥ 1 cm were investigated and monitored to evaluate malignant transformation. Clinical and hepatic serological data were recorded. Results Forty-six patients, median age of 16.5 years (15.4–17.9 years) were enrolled. All patients underwent US examination and MRI was performed in 35/46 patients. On MRI, 60% had hepatomegaly and 37% had signs of fibrosis/cirrhosis. Seven patients had together 13 nodules ≥ 1 cm in diameter. Only 4/13 (17%) where seen on US. Nodules had variable MRI signal characteristics including hepatobiliary contrast enhancement and two nodules revealed portal venous phase ‘wash-out’ on the first examination. No further imaging signs of malignancy were revealed during the follow-up period of median 24.4 (7–42) months. Conclusion The majority of adolescents with Fontan circulation had imaging findings of fibrosis/cirrhosis of varying severity. US had low detection rate of hepatic nodules compared to MRI. The imaging work-up before transition to adult cardiology care did not reveal findings suggestive of malignancy. However, the high prevalence of Fontan-associated liver disease calls for surveillance strategies even in childhood.



2021 ◽  
Vol 71 ◽  
pp. 39-43
Author(s):  
Roya Rezvani Habibabadi ◽  
Joseph H. Huntley ◽  
Rozita Jalilianhasanpour ◽  
David M. Yousem
Keyword(s):  


2020 ◽  
Vol 148 (4) ◽  
pp. 2488-2488
Author(s):  
Matthew Huber ◽  
Katelyn Flint ◽  
James Long ◽  
Will Long ◽  
Nick Bottenus ◽  
...  


2018 ◽  
Vol 37 (4) ◽  
pp. S470-S471
Author(s):  
C.J. van Niekerk ◽  
A.C. Pandey ◽  
J.T. Heywood ◽  
A.V. Srivastava ◽  
R. Mohan
Keyword(s):  


Radiology ◽  
2017 ◽  
Vol 285 (3) ◽  
pp. 763-777 ◽  
Author(s):  
Stephanie B. Shamir ◽  
Jessica Kurian ◽  
Debora Kogan-Liberman ◽  
Benjamin H. Taragin


2017 ◽  
Vol 26 (4) ◽  
pp. 411-422 ◽  
Author(s):  
H.L. Lewis ◽  
M.A. Ghasabeh ◽  
P. Khoshpouri ◽  
I.R. Kamel ◽  
T.M. Pawlik


2016 ◽  
Vol 43 (8Part1) ◽  
pp. 4877-4890 ◽  
Author(s):  
Yuan Yao ◽  
Joshua M. Ng ◽  
Alec J. Megibow ◽  
Norbert J. Pelc


2016 ◽  
Vol 41 (4) ◽  
pp. 600-616 ◽  
Author(s):  
Joseph Ralph Kallini ◽  
Frank H. Miller ◽  
Ahmed Gabr ◽  
Riad Salem ◽  
Robert J. Lewandowski
Keyword(s):  




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