Risk Factors and Causes of Fever after Endoscopic Submucosal Dissection

Background To investigate the fever and related risk factors of gastrointestinal mucosa or submucosal lesions after endoscopic mucosal dissection(ESD).Method A retrospective analysis of patients undergoing ESD. Patients were divided into two groups according to the presence or absence of post-ESD fever. Patient-related factors and lesion-related factors were counted in both groups.Results The incidence of fever was 31.0% in 290 patients after the operation, 87 patients developed fever within 24 hours after operation. The average of (2.82 ± 1.186) days. According to logistic analysis, the surgical site was in the esophagus (OR value: 6.439; 95% CI: 2.030-20.424; P value: 0.002), with diabetes history (OR value: 3.289; 95% CI: 1.015-10.662; P value: 0.047), age≥70.6 years (OR value: 0.844; 95% CI: 0.805-0.884; P value: 0.000), resection diameter> 4.25 mm (OR value: 2.361; 95% CI: 5.202-29.371; P value: 0.000), operation time> 196min (OR value: 1.022; 95% CI: 1.003-1.042; P value: 0.022) were risk factors for fever.Conclusions Older patient, the operation site in esophagus, diabetes, large tumors and long operation time were more likely to develop post-ESD fever, The possibility of bacteremia after ESD is small, antibiotics do not need to be applied in advance.