Mathematical modeling of cardiovascular system provides an ability to study hemodynamics and to predict the results of treatment based on individual anatomical and physiological data of patients. However, the presently developed models of cardiovascular system have a limitation on use in clinical practice due to their physical and computational complexities. The aim of this study is to derive a lumped parameter model of cardiovascular system with pulsating heart in which all parameters have a physically based quantitative value and can be identified using clinical methods. For development of a cardiovascular system model the chamber analog was used which describes whole cardiovascular system as a set of elastic chambers. The proposed model consists of systemic and pulmonary circulation, four-chamber heart and four valves. The description of heart is based on a four-element representation of a cardiac muscle. The reverse blood flow via valves is considered. The accuracy of the derived model was evaluated by comparing the data of numerical simulation with experimental data. The limitations of the model were discussed as well as possible applications of the model were suggested. The proposed lumped parameter model can be used to support clinicians in their decisions in treating cardiovascular disorders.
Cardiovascular System Model-Based Phenotyping of Heart Failure with Preserved Ejection Fraction
