Ruthenium Catalyzed β-Selective Alkylation of Vinylpyridines with Aldehydes/Ketones via N2H4 Mediated Deoxygenative Couplings

Umpolung (polarity reversal) tactics of aldehydes/ketones have greatly broadened the carbonyl chemistry by enabling transformations with electrophilic reagents and deoxygenative functionalizations. Herein, we reported the first ruthenium-catalyzed β-selective alkylation of...

Selective alkylation of parallel G-quadruplex structure

We achieve selective alkylation of parallel G-quadruplex DNA using a conjugate of a macrocyclic hexaoxazole and a sulfoxide precursor to a vinyl-quinazolinone.

Direct Functionalization of Quinoxalin-2(1H)-one with Alkanes: C(sp2)−H/C(sp3)−H Cross Coupling in Transition Metal-Free Mode

Considering the significance of pharmaceutically important heterocycles, efficient and highly versatile protocols for the functionalization of diverse heterocycles with easily accessible feedstock are crucial. Here, we have reported selective alkylation...

Scandium-catalyzed highly selective N2-alkylation of benzotriazoles with cyclohexanones

A scandium-catalyzed highly N2-selective alkylation of benzotriazoles with cyclohexanones has been developed.