cardiac hormones
Recently Published Documents


TOTAL DOCUMENTS

50
(FIVE YEARS 1)

H-INDEX

13
(FIVE YEARS 0)

Author(s):  
Chungyu PAI ◽  
Shunya NAKAYAMA ◽  
Yasuyo ITO-FUJISHIRO ◽  
Kiichi KANAYAMA ◽  
Yoshiko MUNESUE ◽  
...  

2018 ◽  
Vol 80 (7) ◽  
pp. 1165-1173
Author(s):  
Shunya NAKAYAMA ◽  
Hiroshi KOIE ◽  
Kiichi KANAYAMA ◽  
Yuko KATAKAI ◽  
Yasuyo ITO-FUJISHIRO ◽  
...  

2013 ◽  
pp. n/a-n/a ◽  
Author(s):  
Neil J. Manimala ◽  
Chelsea D. Frost ◽  
Meghan L. Lane ◽  
Mariana Higuera ◽  
Rana Beg ◽  
...  

2013 ◽  
Vol 20 (3) ◽  
pp. R113-R125 ◽  
Author(s):  
David L Vesely

Four cardiac hormones, namely atrial natriuretic peptide, vessel dilator, kaliuretic peptide, and long-acting natriuretic peptide, reduce up to 97% of all cancer cellsin vitro. These four cardiac hormones eliminate up to 86% of human small-cell lung carcinomas, two-thirds of human breast cancers, and up to 80% of human pancreatic adenocarcinomas growing in athymic mice. Their anticancer mechanisms of action, after binding to specific receptors on cancer cells, include targeting the rat sarcoma-bound GTP (RAS) (95% inhibition)–mitogen-activated protein kinase kinase 1/2 (MEK 1/2) (98% inhibition)–extracellular signal-related kinase 1/2 (ERK 1/2) (96% inhibition) cascade in cancer cells. They also inhibit MAPK9, i.e. c-Jun N-terminal kinase 2. They are dual inhibitors of vascular endothelial growth factor (VEGF) and its VEGFR2 receptor (up to 89%). One of the downstream targets of VEGF is β-catenin, which they reduce up to 88%. The WNT pathway is inhibited up to 68% and secreted frizzled-related protein 3 decreased up to 84% by the four cardiac hormones. AKT, a serine/threonine protein kinase, is reduced up to 64% by the cardiac hormones. STAT3, a final ‘switch’ that activates gene expression that leads to malignancy, is decreased by up to 88% by the cardiac hormones. STAT3 is specifically decreased as they do not affect STAT1. There is a cross-talk between the RAS–MEK 1/2–ERK 1/2 kinase cascade, VEGF, β-catenin, WNT, JNK, and STAT pathways and each of these pathways is inhibited by the cardiac hormones.


2012 ◽  
Vol 60 (16) ◽  
pp. 1558-1565 ◽  
Author(s):  
Fima Macheret ◽  
Denise Heublein ◽  
Lisa C. Costello-Boerrigter ◽  
Guido Boerrigter ◽  
Paul McKie ◽  
...  

2012 ◽  
Vol 371 (1-2) ◽  
pp. 209-215 ◽  
Author(s):  
Meghan L. Lane ◽  
Chelsea D. Frost ◽  
Jennifer P. Nguyen ◽  
William P. Skelton ◽  
Michelle Skelton ◽  
...  

Sign in / Sign up

Export Citation Format

Share Document