in situ esterification
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Without employing high dilution conditions, the fourfold 2+2 Perkin reaction of 1,6-pyrenylene-diglyoxylic acid with its reduction product 1,6-pyrenylene-diacetic acid yields the corresponding tetrameric conjugated macrocycle in 25% overall yield after in-situ esterification. The macrocycle adopts a square fourfold symmetry in the crystal, with near-vertical pyrene walls that alternatingly tilt upwards and downwards.


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