Paniculitis en pancreatitis aguda. Reporte de un caso y revisión de la literatura

Pancreatic panniculitis is a cutaneous manifestation that can occur as a complication of acute pancreatitis. We present the case of a patient who had an acute pancreatitis initially classified as mild, but, during the course of the disease, was associated with the presence of an exacerbation of pain together with erythematous, painful and well-defined dorsal lesions. In the tomographic control, the presence of the panniculitis and peri-pancreatic necrosis with periportal gas was confirmed. The patient had a clinical decompensation associated with the suspicion of compartment syndrome. For this reason, it was decided to perform an exploratory laparotomy. The presentation of pancreatic paniculitis is an infrequent manifestation, thus we consider pertinent the description of this case and its review in the literature.

Pancreatic Acinar Cell Carcinoma with Germline BRCA2 Mutation and Severe Pancreatic Panniculitis: A Case Report

Pancreatic acinar cell carcinoma (ACC) is a rare malignant disease that displays distinct differences to pancreatic ductal adenocarcinoma. Here, we report the case of a patient with ACC and underlying breast cancer susceptibility gene 2 (BRCA2) germline mutation that developed severe pancreatic panniculitis (PP) during the course of the disease. The patient received a multimodal therapy including surgery, systemic chemotherapy, and targeted therapy with the PARP inhibitor olaparib, resulting in an overall survival of 47 months. Findings from this case are compared to the current knowledge on management of ACC and paraneoplastic PP.