Insights into the Morita–Baylis–Hillman reaction of isomeric dibenzofuran carbaldehydes: a theoretical and mass spectral study

Systematic theoretical and mass spectral investigations on the faster Morita–Baylis–Hillman (MBH) reaction of dibenzofuran-4-carbaldehyde (2) compared to its isomer, dibenzofuran-2-carbaldehyde (1) are described.

Synthesis and Antibacterial, Antimycobacterial Activity of 7-[4-{5-(2-Oxo-2-p-substituted-phenylethylthio)-1,3,4-thiadiazol-2yl}-3′-methylpiperazinyl] Quinolone Derivatives

Currently we screened 9 newer synthesized fluoroquinolone derivatives5(a–i)against two gram positive, two gram negative bacterial strains, and mycobacterium tuberculosis H37Rv. These analogues were confirmed by IR,1H NMR,13C NMR, and elemental analysis. Selected compounds were confirmed by mass spectral study. Compounds5(b–d)showed comparable biological activities and other analogues of the series showed moderate-to-weak activity, as compared to the reference marketed drugs.