A Bra Monitoring System Using a Miniaturized Wearable Ultra-Wideband MIMO Antenna for Breast Cancer Imaging

This paper represents a miniaturized, dual-polarized, multiple input–multiple output (MIMO) wearable antenna. A vertically polarized, leaf-shaped antenna and a horizontally polarized, tree-shaped antenna are designed, and the performance of each antenna is investigated. After designing the MIMO antenna, it is loaded with stubs, parasitic spiral, and shorting pins to reduce the coupling effects and remove the unwanted resonances. Afterward, the two-port MIMO cells are spaced by 2 mm and rotated by 90° to create three more cells. The antennas are designed using two layers of denim and felt substrates with dielectric constants of 1.2 and 1.8, and thicknesses of 0.5 mm and 0.9 mm, respectively, along with the ShieldIt™ conductive textile. The antenna covers a bandwidth of 4.8–30 GHz when the specific absorption rate (SAR) meets the 1 g and 10 g standards. Isolation greater than 18 dB was obtained and mutual coupling was reduced after integrating shorting pins and spiral parasitic loadings. A maximum radiation efficiency and directive gain of 96% and 5.72 dBi were obtained, respectively, with the relatively small size of 11 × 11 × 1.4 mm3 for the single element and final dimensions of 24 × 24 × 1.4 mm3 for the full assembly. The antenna’s performance was examined for both on-body (breast) and free space conditions using near-field microwave imaging. The achieved results such as high fidelity, low SAR, and accuracy in localization of the tumour indicate that the MIMO antenna is a decent candidate for breast cancer imaging.

Second-generation optoacoustic imaging of breast cancer patients

Since the initial breast transillumination almost a century ago, breast cancer imaging using light has been considered in different implementations aiming to improve diagnostics, minimize the number of available biopsies, or monitor treatment. However, due to strong photon scattering, conventional optical imaging yields low resolution images, challenging quantification and interpretation. Optoacoustic imaging addresses the scattering limitation and yields high-resolution visualization of optical contrast, offering great potential value for breast cancer imaging. Nevertheless, the image quality of experimental systems remains limited due to a number of factors, including signal attenuation with depth and partial view angle and motion effects, particularly in multi-wavelength measurements. We developed data analytics methods to improve the accuracy of handheld optoacoustic breast cancer imaging, yielding second-generation optoacoustic imaging performance operating in tandem with ultrasonography. We produced the best images yet with handheld optoacoustic examinations of the human breast and breast cancer, in terms of resolution and contrast. Using these advances, we examined optoacoustic markers of malignancy, including vasculature abnormalities, hypoxia, and inflammation, on images obtained from breast cancer patients. We achieved the best optoacoustic images of the human breast ever obtained using handheld examination, advancing the diagnostic and theranostic potential of the hybrid optoacoustic-ultrasound (OPUS) examination over routine ultrasonography.