Immunosenescence : Penuaan Pada Sel Makrofag

Immune function will decrease with age. The weakening of immune system is known as immunosenescence.Macrophages that play a major role in carrying out innate and adaptive immune functions have potential to undergoaging (macrophaging). Some potential mechanisms that can affect the aging of macrophages include telomereshortening, oxidative damage and impaired DNA repair processes. The impact of macrophaging can be a decreasenumber of macrophages in bone marrow, changing cytokine secretion, decreasing class II MHC expression, changingmacrophages polarization, decreasing ability of phagocytosis, and decreasing ability of wound repair and tissueregeneration.

THE FISHBURN METHOD AS A META-MATHEMATIC STATISTICAL APPROACH IN EVALUATION OF THE ROLE OF COMMON AND ATYPICAL AGENTS IN THE ETIOLOGIC STRUCTURE OF COMMUNITY-ACQUIRED PNEUMONIA IN ADULTS

The actual guidelines on treatment of pneumonia emphasize necessity of establishment of etiologic diagnosis for therapy rationale. The necessity occurs to group agents according significance of their effect at evaluating etiologic role of a number of agents, for instance under implementation of epidemiological investigations, studying of etiologic structure of infections, planning of medicinal support. In that case, the Fishburn method fits perfectly. The purpose of study is to implement Fishburn method in establishing role of traditional and atypical agents in etiologic structure of community-acquired pneumonia.Materials and methods. The sampling included 172 examined patients aged from 18 to 30 years being under hospital treatment with confirmed diagnosis of community-acquired pneumonia. The analysis was applied to such biologic substrates as phlegm, blood, lavage (bronchoalveolar fluid). The technique of polymerase chain reaction was used. To determine weight coefficients of every analyzed etiologic agents with their subsequent distribution according percentage in etiologic structure. The Fishburn method was applied. The results. The main agents were established Streptococcus pneumoniae (separated in 86,3% of patients) and Haemophilus influenzae (41,2%). The mixed infection occurred in 65.8% of examined patients. The most propagated are such associations as Streptococcus pneumoniae and Haemophilus influenzae, Streptococcus pneumoniae and M. pneumoniae. Conclusion. S. pneumoniae, H. influenzae, M. pneumoniae are independent infection agents related to high and average levels. In the most cases, the detected agents were found in associations. A significant rate of detection of Herpes simplex I/II (16,2%) in blood and saliva of patients with community-acquired pneumonia testifies weakening of immune system. Herpes simplex I/II worsens course of diseases but is not considered as independent infection agent. The data obtained has epidemiological significance and can impact on development of medication support.