Rhodium(III)-Catalyzed Synthesis of Trisubstituted Furans via Vinylic C-H Bond Activation

We report a Rh(III)-catalyzed one-pot synthesis of trisubstituted furan derivatives through Cvinyl-H activation of α,β-unsaturated ketone derivatives with acrylate ester as a coupling partner. The control study revealed that the...

Synthesis of 2-acetyl trisubstituted furans via copper-mediated deacylation cleavage of unstrained C(sp3)–C(sp2) bonds

A copper-mediated tandem addition/cyclization/carbon–carbon cleavage reaction for the convenient synthesis of 2-acyl trisubstituted furans has been developed.

New Efficient Synthesis of 1,2,4-Trisubstituted Furans by a ­Sequential Passerini/Wittig/Isomerization Reaction Starting from Baylis–Hillman β-Bromo Aldehydes

A new and efficient synthesis of 1,2,4-trisubstituted furans from a Baylis–Hillman β-bromo aldehyde, an acid, an isocyanide, and methyl(diphenyl)phosphine, by a sequential Passerini condensation, Wittig reaction, and isomerization in the presence of triethylamine is reported.