Immunocompetent cells in the tissue of adhesives of patients with adhesion process in the small pelvis

Objective: To study the morphological features and subpopulation composition of immunocompetent cells of adhesion tissue in women with adhesions of the pelvic organs.Materials and Methods: Th e study was carried out using surgical material obtained from 70 women aged 23 to 40 years. Of these, 50 tissue samples of peritoneal adhesions from patients with adhesions of organs in the small pelvis of I – II degree who underwent adhesiolysis and 20 samples of parietal peritoneum from healthy women who underwent endoscopic sterilization for contraception or completion of generative function. Th e authors used histological, immunohistochemical, and morphometric research methods.Results: Immunological changes in adhesion tissue were characterized by the activation of the T-cell link of immunity. It was confi rmed by a signifi cant increase in the content of CD4+ (p <0.001), CD8+ (p <0.001), a shift in the balance of immunoregulatory subpopulations towards CD8+, a lower indicator of the immunoregulatory index (p = 0.015), and insuffi ciency of the humoral link of immunity, namely, the absence of CD20+ content against the background of a slight increase in the CD138+ pool.Conclusion: To prevent the postoperative adhesion process in the small pelvis in patients of reproductive age, it is necessary to apply immunomodulatory therapy in the early postoperative period, which will improve the results of surgical treatment and is pathogenetically justifi ed.

Structure and severity of pathological anxiety response in the representatives of the command staff of the merchant and passenger navy

During 2016–2019, 180 navy commanders of Ukraine were surveyed: 110 members of the merchant navy command staff and 70 members of command staff of the passenger navy. All surveyed were male, citizens of Ukraine. Clinical-psychopathological and psychodiagnostic methods were used for studying the specific manifestations of anxiety response of the command staff of the merchant and passenger navy, to determine the need to create system-specific measures for the protection of their mental health. It is shown that more than half of the representatives of the command staff of the merchant (69,1 %) and passenger (57,1 %) navy have signs of mental maladaptation, which in most cases do not reach clinically outlined severity. A significant number of command personnel of both the merchant and passenger navy have manifestations of pathological alarming responses and alarming symptoms, predominantly of moderate intensity. In the commanders of the merchant navy more intense manifestations of alarming symptoms are observed, the average severity of which is approaching the upper limit of subclinical values, in representatives of the passenger navy the average severity of alarming symptoms is approaching to the upper limit of the standard indicators. A lower indicator of alarming symptoms among commanders of the passenger navy is due to a significantly larger number of persons without signs of mental maladaptation, while a significantly increased level of alarming response of merchant navy captains is due to a large number of respondents with preclinical maladaptive manifestations. The data obtained should be taken into account in the development of specific measures of psychotherapy and psychoprophylaxis for this contingent, which is the perspective of this study.