muscarinic modulation
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PLoS ONE ◽  
2020 ◽  
Vol 15 (1) ◽  
pp. e0226954 ◽  
Author(s):  
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Stefanie Kurth ◽  
Thomas Kuenzel


2020 ◽  
Vol 13 ◽  
Author(s):  
Fang Zheng ◽  
Barbara E. Nixdorf-Bergweiler ◽  
Elke Edelmann ◽  
Johannes F. M. van Brederode ◽  
Christian Alzheimer


Cell Reports ◽  
2019 ◽  
Vol 29 (10) ◽  
pp. 3253-3265.e4 ◽  
Author(s):  
Eyal Rozenfeld ◽  
Hadas Lerner ◽  
Moshe Parnas






2015 ◽  
Vol 35 (30) ◽  
pp. 10773-10785 ◽  
Author(s):  
R. S. Smith ◽  
R. Hu ◽  
A. DeSouza ◽  
C. L. Eberly ◽  
K. Krahe ◽  
...  


2015 ◽  
Vol 597 ◽  
pp. 1-6 ◽  
Author(s):  
Yoshiaki Ohi ◽  
Daisuke Kato ◽  
Masayuki Mizuno ◽  
Toyohiro Sato ◽  
Yoshino Ueki ◽  
...  


2015 ◽  
Vol 42 (2) ◽  
pp. 1797-1807 ◽  
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P. Rivas-Ramírez ◽  
A. Cadaveira-Mosquera ◽  
J. A. Lamas ◽  
A. Reboreda


2015 ◽  
Vol 113 (3) ◽  
pp. 796-807 ◽  
Author(s):  
Ricardo Hernández-Martínez ◽  
José J. Aceves ◽  
Pavel E. Rueda-Orozco ◽  
Teresa Hernández-Flores ◽  
Omar Hernández-González ◽  
...  

The external globus pallidus (GPe) is central for basal ganglia processing. It expresses muscarinic cholinergic receptors and receives cholinergic afferents from the pedunculopontine nuclei (PPN) and other regions. The role of these receptors and afferents is unknown. Muscarinic M1-type receptors are expressed by synapses from striatal projection neurons (SPNs). Because axons from SPNs project to the GPe, one hypothesis is that striatopallidal GABAergic terminals may be modulated by M1 receptors. Alternatively, some M1 receptors may be postsynaptic in some pallidal neurons. Evidence of muscarinic modulation in any of these elements would suggest that cholinergic afferents from the PPN, or other sources, could modulate the function of the GPe. In this study, we show this evidence using striatopallidal slice preparations: after field stimulation in the striatum, the cholinergic muscarinic receptor agonist muscarine significantly reduced the amplitude of inhibitory postsynaptic currents (IPSCs) from synapses that exhibited short-term synaptic facilitation. This inhibition was associated with significant increases in paired-pulse facilitation, and quantal content was proportional to IPSC amplitude. These actions were blocked by atropine, pirenzepine, and mamba toxin-7, suggesting that receptors involved were M1. In addition, we found that some pallidal neurons have functional postsynaptic M1 receptors. Moreover, some evoked IPSCs exhibited short-term depression and a different kind of modulation: they were indirectly modulated by muscarine via the activation of presynaptic cannabinoid CB1 receptors. Thus pallidal synapses presenting distinct forms of short-term plasticity were modulated differently.



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