Epstein–Barr Virus: Should We Still Invest in Vaccines or Focus on Predictive Tests?

The complex interplay between host and EBV has made it difficult to elaborate useful vaccines protecting against EBV diseases. It is encouraging to see that EBV vaccine programs have started to incorporate different arms of the immune system. An array of argument calls for a realistic goal for vaccine strategies which should be preventing EBV diseases, rather than EBV infection. EBV is the primary cause of infectious mononucleosis and is associated with epithelial cell carcinomas, as well as lymphoid malignancies. Parallel to this need, one could propose priorities for future research: (i) identification of surrogate predictive markers for the development of EBV diseases (ii) determination of immune correlates of protection in animal models and humans.

Ease and Difficulty in L2 Pronunciation Teaching: A Mini-Review

Both L2 learners and their teachers are concerned about pronunciation. While an unspoken classroom goal is often native-accented speech (i.e., a spoken variety of the mother tongue that it not geographically confined to a place within a particular country), pronunciation researchers tend to agree that comprehensible speech (i.e., speech that can be easily understood by an interlocutor) is a more realistic goal. A host of studies have demonstrated that certain types of training can result in more comprehensible L2 speech. This contribution considers research on training the perception and production of both segmental (i.e., speech sounds) and suprasegmental features (i.e., stress, rhythm, tone, intonation). Before we can determine whether a given pronunciation feature is easy or difficult to teach and—more importantly—to learn, we must focus on: 1) setting classroom priorities that place comprehensibility of L2 speech at the forefront; and 2) relying upon insights gained through research into L2 pronunciation training. The goal of the mini-review is to help contextualize the papers presented in this collection.

Filling and retouching of losses in a Portuguese Army model 1859 clothes backpack

Two identical backpacks were treated on two occasions to be exhibited alongside at the Lisbon Military Museum. Although both backpacks are the model 1859, the treatment procedures related to the painted canvas were approached differently. The distortions and losses of canvas on the first treated backpack were easily addressed with an ultrasonic humidifier and the insertion of new canvas. Regarding the surface coating, it was consolidated with BEVA® 371, and the inserted canvas was filled with a pigmented wax paste described in a book from the late 19th century. The second backpack was in far worse condition, which, when compared with archive record, seemed likely that it was exhibited for a long period in a damp environment. There were also traces of an organic coating distinct from the original coating. These conditions resulted in a stiffer backpack, with more losses of canvas and surface coating. As a result, the distortions could not be removed, new fabric could not be properly inserted, and the consolidation of the surface coating had to be addressed in a different way. For these motives, the goal of treatment of the second treated backpack was cut short for a more realistic goal, but resulted in a good outcome, nonetheles.

From therapeutic drug monitoring to total drug monitoring and drug-omics

In view of the role of pharmacotherapy in medicine, on the one hand, and the powerful technical possibilities that are now available on the other hand, therapeutic drug monitoring is a surprisingly neglected area of laboratory medicine. In this viewpoint article, an “omics approach” to pharmacovigilance and drug monitoring is proposed and discussed. A realistic goal for laboratory medicine in the 21st century should indeed be to enable clinicians to check whether the right drug is present in the right patient with an appropriate blood concentration for each compound.

Tarsal fractures: part 2

Both calcaneal and central tarsal bone fractures are commonly encountered in the racing greyhound. While isolated fractures of the numbered tarsal bones are uncommon, malleolar fractures are encountered frequently in small animal practice. Fractures of the central tarsal bone or calcaneal fractures in both dogs and cats may be either fatigue or stress fractures, or associated with Knees and Teeth Syndrome, which may alter the typically expected presentation and prompt assessment for additional fractures, both in the tarsus and elsewhere. Surgical stabilisation is often the treatment of choice, particularly for fractures with an articular component. In many cases, surgical stabilisation leads to a positive outcome, with Greyhounds often being able to return to racing. However, it is important to be aware that fractures in non-racing dogs tend to be more complex and that this good prognosis may not be appropriate to extrapolate. Depending on the nature and severity of injuries, joint preservation may not always be a realistic goal. If the joint cannot be preserved, arthrodesis may become necessary.