Use of Micro-CT Imaging to Assess Ventral Mandibular Cortical Thickness and Volume in an Experimental Rodent Model With Chronic High-Phosphorus Intake

Adverse effects of high dietary phosphorus on bone health have been observed in both animal and human studies. The aim of the investigation was to examine chronic effects of high phosphorus diet on the apical mandibular cortical thickness and volume in a hystricomorph rodent (Octodon degus) using microcomputed tomography. Male degus were randomly divided into two groups fed by different mineral contents from the age of 12 weeks till the age of 17 months. The micro-CT scanning and wall thickness analysis were applied on the region of the mandible exactly under the apices of the 4th premolar tooth, first molar tooth, and second molar tooth in two animals from each group. General overview and mapping of the ventral mandibular bone thickness revealed pronounced bony mandibular protrusions in all the animals fed a high-phosphorus diet with obvious bone thinning apically to the 4th premolar and first and second molar tooth apices. Mandibular bone volume and thickness located apically to the premolar and molars were statistically significantly smaller/thinner in the group fed by a high phosphorus diet. The thinnest bone measured 0.004 mm, where the mandibular 4th premolar tooth almost perforated the mandibular cortex. Similar studies of metabolic bone disease and its influence on alveolar bone were also published in rats and mice. The influence of different environmental, infectious, or metabolic factors on the growing tooth, alveolar bone formation, and bone pathologies must be done experimentally on growing animals. In contrast, degus have continuously growing dentition, and the effect of any of the above listed factors can be studied in this animal model at any age and for longer time periods.

Plasma Calcium and Phosphorus In Weanling Pigs as Influenced by Dietary Calcium: Phoshporus Ratio and Cestrum Diurnum Ingestion

Twenty Yorkshire piglets weaned at approximately 4 weeks of age, were used in this study to investigate the variations in plasma calcium and phosphorus as influenced by dietary calcium and phosphorus and 3 Cestrum diurnum. In the CCD and TCD pigs, hypercalcemia developed rapidly and persisted following the feeding of 3% C. diurnum. While hypophosphatemia occurred in the CCD pigs, there was an initial and transient hyperphosphatemia with subsequent and terminal hypophosphatemia in the TCD pigs The hypercalcemia induced by the ingestion of 5% C. diurnum in the CCD and TCD pigs is attributed to increased intestinal absorption of calcium and not to bore resorption. The initial hyperphosphatemic response in TCD pigs is also believed to be due to increase absorption of phosphorus from the high phosphorus diet.

Osteodystrophia Fibrosa in a Goat - A case report

Osteodystrophia fibrosa is a condition associated with fibrous replacement of the resorbed bony matrix. In India, it is commonly reported in horses, and is most often associated with bran feeding, leading to higher availability of phosphorus and imbalance in the calcium phosphorus ratio. Low calcium or high phosphorus diet can result in secondary nutritional hyperparathyroidism leading to osteodystrophia fibrosa (Ozmen et al., 2017). Bone resorption of calcium occurs associated with low calcium level in circulation. Deformities of the bone manifests associated with the severity of the condition.