airway cilia
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Author(s):  
Randy Suryadinata ◽  
Kovi Levin ◽  
Lynda Holsworth ◽  
Miranda Paraskeva ◽  
Philip Robinson

2020 ◽  
Vol 10 (1) ◽  
Author(s):  
Ryosuke Nakamura ◽  
Tatsuya Katsuno ◽  
Yo Kishimoto ◽  
Shinji Kaba ◽  
Masayoshi Yoshimatsu ◽  
...  

2020 ◽  
Vol 39 (4) ◽  
pp. S125
Author(s):  
R. Suryadinata ◽  
K. Levin ◽  
L. Holsworth ◽  
M. Paraskeva ◽  
P.J. Robinson
Keyword(s):  

2020 ◽  
Vol 21 (6) ◽  
pp. 1947
Author(s):  
Haruka Kogiso ◽  
Matthieu Raveau ◽  
Kazuhiro Yamakawa ◽  
Daichi Saito ◽  
Yukiko Ikeuchi ◽  
...  

In Ts1Rhr, a Down syndrome model mouse, the airway ciliary beatings are impaired; that is, decreases in ciliary beat frequency (CBF) and ciliary bend angle (CBA, an index of ciliary beat amplitude)). A resumption to two copies of the Pcp4 gene on the Ts1Rhr trisomic segment (Ts1Rhr:Pcp4+/+/-) rescues the decreases in CBF and CBA that occur in Ts1Rhr. In airway cilia, upon stimulation with procaterol (a β2-agonist), the CBF increase is slower over the time course than the CBA increase because of cAMP degradation by Ca2+/calmodulin-dependent phosphodiesterase 1 (PDE1) existing in the metabolon regulating CBF. In Ts1Rhr, procaterol-stimulated CBF increase was much slower over the time course than in the wild-type mouse (Wt) or Ts1Rhr:Pcp4+/+/-. However, in the presence of 8MmIBMX (8-methoxymethyl isobutylmethyl xanthine, an inhibitor of PDE1) or calmidazolium (an inhibitor of calmodulin), in both Wt and Ts1Rhr, procaterol stimulates CBF and CBA increases over a similar time course. Measurements of cAMP revealed that the cAMP contents were lower in Ts1Rhr than in Wt or in Ts1Rhr:Pcp4+/+/-, suggesting the activation of PDE1A that is present in Ts1Rhr airway cilia. Measurements of the intracellular Ca2+ concentration ([Ca2+]i) in airway ciliary cells revealed that temperature (increasing from 25 to 37 °C) or 4αPDD (a selective transient receptor potential vanilloid 4 (TRPV4) agonist) stimulates a larger [Ca2+]i increase in Ts1Rhr than in Wt or Ts1Rhr:Pcp4+/+/-. In airway ciliary cells of Ts1Rhr, Pcp4-dose dependent activation of TRPV4 appears to induce an increase in the basal [Ca2+]i. In early embryonic day mice, a basal [Ca2+]i increased by PCP4 expressed may affect axonemal regulatory complexes regulated by the Ca2+-signal in Ts1Rhr, leading to a decrease in the basal CBF and CBA of airway cilia.


2018 ◽  
Vol 471 (2) ◽  
pp. 365-380 ◽  
Author(s):  
Yukiko Ikeuchi ◽  
Haruka Kogiso ◽  
Shigekuni Hosogi ◽  
Saori Tanaka ◽  
Chikao Shimamoto ◽  
...  
Keyword(s):  

Author(s):  
M Wildung ◽  
C Herr ◽  
M Alevra ◽  
S Andreas ◽  
D Riedel ◽  
...  
Keyword(s):  

Alcohol ◽  
2018 ◽  
Vol 66 ◽  
pp. 93
Author(s):  
M.E. Price ◽  
J.A. Pavlik ◽  
D. Katafiasz ◽  
K.L. Bailey ◽  
J.H. Sisson
Keyword(s):  

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