EFFECTS OF VOLATILE ORGANIC ALKILNYTRITIS COMPOUNDS ON THE ORGANISM AND THE POSSIBILITY OF THEIR FORENSIC CHEMICAL DETECTING

The article reviews and summarizes theoretical issues related to the abuse of inhalants, provides data on the pharmacological and toxic effects, the legal status of the substances under study, the chemical analysis of alkyl nitrites. The risk to human health is associated with the ability of alkyl nitrites to cause methemoglobin, changes in organs and systems, including myocardial dystrophy, chronic inflammation of the upper respiratory tract. The use of isopropyl nitrite can cause damage to the retina, maculapathy. ”Poppers” is a subgroup of volatile substances – alkyl nitrites, represented by compounds or mixtures and contain more than one alkyl nitrite, mainly: butyl nitrite, isobutyl nitrite or amyl nitrite, isopentyl nitrite, or 2-methyl butyl nitrite. On the Internet market they are presented under the following slang names: amyls, hardware, liquid gold, locker room, rock hard, rush, snapper, TNT . Chemico-toxicological analysis is carried out by chromatography methods – the vapor phase analysis with identification on a flame-ionization or mass-selective detector is used. Blood, in cases of deadly intoxication, lung tissue are the best objects. One of the signs of using alkyl nitrites is the formation of methemoglobin, the definition of which has an important diagnostic value. Joint detection of metabolites of alkyl nitrites and methemoglobin may indicate the possible use of alkyl nitrites. The legal status of alkyl nitrites in most countries varies from free use to medical prescription sales. In the Republic of Kazakhstan, alkyl nitrites are not under the control of the law “On Narcotic Drugs, Psychotropic Substances, Their Analogues and Precursors, and Measures to Counteract Their Illicit Circulation and Abuse”. Their abuse is a concern because of their detrimental health effects. Key words: alkyl nitrite, toxicomania, poppers, methemoglobinemia, maculopathy, forensic expertise, research, chemical analysis.

HO_<i>x</i> and NO_<i>x</i> production in oxidation flow reactors via photolysis of isopropyl nitrite, isopropyl nitrite-d₇, and 1,3-propyl dinitrite at <i>λ</i> = 254, 350, and 369 nm

Oxidation flow reactors (OFRs) are an emerging technique for studying the formation and oxidative aging of organic aerosols and other applications. In these flow reactors, hydroxyl radicals (OH), hydroperoxyl radicals (HO2), and nitric oxide (NO) are typically produced in the following ways: photolysis of ozone (O3) at λ=254 nm, photolysis of H2O at λ=185 nm, and via reactions of O(1D) with H2O and nitrous oxide (N2O); O(1D) is formed via photolysis of O3 at λ=254 nm and/or N2O at λ=185 nm. Here, we adapt a complementary method that uses alkyl nitrite photolysis as a source of OH via its production of HO2 and NO followed by the reaction NO + HO2 → NO2 + OH. We present experimental and model characterization of the OH exposure and NOx levels generated via photolysis of C3 alkyl nitrites (isopropyl nitrite, perdeuterated isopropyl nitrite, 1,3-propyl dinitrite) in the Potential Aerosol Mass (PAM) OFR as a function of photolysis wavelength (λ=254 to 369 nm) and organic nitrite concentration (0.5 to 20 ppm). We also apply this technique in conjunction with chemical ionization mass spectrometer measurements of multifunctional oxidation products generated following the exposure of α-Pinene to HOx and NOx obtained using both isopropyl nitrite and O3 + H2O + N2O as the radical precursors.

HO_x and NO_x production in oxidation flow reactors via photolysis of isopropyl nitrite, isopropyl nitrite-d₇, and 1,3-propyl dinitrite at λ = 254, 350, and 369 nm

Oxidation flow reactors (OFRs) are an emerging technique for studying the formation and oxidative aging of organic aerosols and other applications. In these flow reactors, hydroxyl radicals (OH), hydroperoxyl radicals (HO2), and nitric oxide (NO) are typically produced in the following ways: photolysis of ozone (O3) at λ = 254 nm, photolysis of H2O at λ = 185 nm, and via reactions of O(1D) with H2O and nitrous oxide (N2O); O(1D) is formed via photolysis of O3 at λ = 254 nm and/or N2O at λ = 185 nm. Here, we adapt a complementary method that uses alkyl nitrite photolysis as a source of OH via its production of HO2 and NO followed by the reaction NO + HO2 → NO2 + OH. We present experimental and model characterization of the OH exposure and NOx levels generated via photolysis of C3 alkyl nitrites (isopropyl nitrite, perdeuterated isopropyl nitrite, 1,3-propyl dinitrite) in the Potential Aerosol Mass (PAM) OFR as a function of photolysis wavelength (λ = 254 to 369 nm) and organic nitrite concentration (0.5 to 20 ppm). We also apply this technique in conjunction with chemical ionization mass spectrometer measurements of multifunctional oxidation products generated following the exposure of α-pinene to HOx and NOx obtained using both isopropyl nitrite and O3 + H2O + N2O as the radical precursors.

An Efficient Cyanide-Free Approach towards 1-(2-Pyridyl)isoquinoline-3-carbonitriles via the Reaction of 5-Phenacyl-1,2,4-triazines with 1,2-Dehydrobenzene in the Presence of Alkyl Nitrites

A cyanide-free method for the preparation of 1-(2-pyridyl)isoquinoline-3-carbonitriles (3-cyanoisoquinolines) was developed. The interaction of 5-phenacyl-3-(2-pyridyl)-1,2,4-triazines with 1,2-dehydrobenzene generated in situ from anthranilic acid and an excess of amyl nitrites afforded the target compounds in good yields. The proposed mechanism involves the in situ transformation of the 5-phenacyl group into the 5-cyano group under the action of alkyl nitrite and the following inverse demand aza-Diels–Alder reaction of thus formed 5-cyano-1,2,4-triazines with 1,2-dehydrobenzene affording the target products. The presence of the 5-phenacyl substituent is a key for the reaction, as in case of 5-styryl- or 5-phenylethynyl-3-(2-pyridyl)-1,2,4-triazines the formation of the 1,2,4-triazine ring-transformation products was observed