Organotin(IV) complexes with o- or p-hydroxybenzoic acids (o-H2BZAor p-H2BZA) of formulae[R2Sn(HL)2](whereH2L= o-H2BZAand R = Me- (1),n-Bu- (2));[R3Sn(HL)](whereH2L= o-H2BZAand R =n-Bu- (3), Ph- (4) orH2L= p-H2BZAand R =n-Bu- (5), Ph- (6)) were synthesized by reacting a methanolic solution of di- and triorganotin(IV) compounds with an aqueous solution of the ligand (o-H2BZAor p-H2BZA) containing equimolar amounts of potassium hydroxide. The complexes were characterized by elemental analysis, FT-IR, Far-IR, TGA-DTA, FT-Raman, Mössbauer spectroscopy,H1,S119n-NMR, UV/Vis spectroscopy, and Mass spectroscopy. The X-ray crystal structures of complexes1and2have also been determined. Finally, the influence of these complexes1–6upon the catalytic peroxidation of linoleic acid to hydroperoxylinoleic acid by the enzyme lipoxygenase (LOX) was kinetically studied and the results showed that triorganotin(IV) complex6has the lowestIC50value. Also complexes1–6were studied for their in vitro cytotoxicity against sarcoma cancer cells (mesenchymal tissue) from the Wistar rat, and the results showed that the complexes have high activity against these cell lines with triphenyltin((IV) complex4to be the most active one.