Iridium(III)-Catalyzed Two-Fold C−H Alkylation of BINOLs with Allyl Alcohols

Ir(III)-catalyzed C−H alkylation of BINOL units has been well examined by allyl alcohols as coupling partners. Under the advantage of pyridine guiding group, the efficient protocol allows the rapid synthesis...

Rhodium(III)-catalyzed oxidative annulation of isoquinolones with allyl alcohols: synthesis of isoindolo[2,1-b]isoquinolin-5(7H)-ones

An efficient rhodium(III)-catalyzed direct C-H oxidative annulation of isoquinolones with allyl alcohols as C1 synthons has been successfully developed. This protocol enables the straightforward synthesis of structurally diverse isoindolo[2,1-b]isoquinolin-5(7H)-ones with...

A Concise Copper-Catalyzed Oxytrifluoromethylation of Allyl Alcohols

An efficient oxytrifluoromethylation of allyl alcohols has been developed using Togni’s reagent II as a trifluoromethylation reagent and cuprous chloride as a catalyst. This reaction proceeded through a one-pot process of trifluoromethylation followed by nucleophilic attack of the vicinal hydroxyl group. This strategy features good diastereoselectivity and broad substrate scope, which provides a facile access to various α-CF3-substituted epoxides.