Inclusion, including students with disabilities in the general education classroom, has become the norm in the United States due to Public Law 94-142 (P.L. 94-142). The requirements of P.L. 94-142, now the Individuals with Disabilities Education Improvement Act (IDEIA), are explained in this chapter. Additionally, school districts are required to provide students with disabilities assistive technologies. Twenty-first century classrooms are now using Apple's iPad on a regular basis, with all students, in place of other assistive technologies. Apple's App Store offers numerous applications that can be used by students with disabilities. The purpose of this chapter is to provide a review of special education laws in the United States, while offering educators, parents, and specialists an overview of applications that have been developed for a variety of disabilities. Each application is categorized and briefly explained. The cost and compatibility with Apple devices is also provided.