A new polyoxygenated cyclohexene, globbanol A (1), 2 other cyclohexene derivatives, crotepoxide (2) and boesenboxide (3), along with a chalcone, 2ʹ- hydroxy-4,4ʹ,6ʹ-trimethoxy-chalcone (4) were isolated from the rhizomes of Globba pendula Roxb. ( Zingiberaceae) of Vietnam. Their structures were elucidated on the basis of extensive analysis of high-resolution electrospray ionization mass spectrometry and NMR spectral data. Absolute configuration of new compound was determined by circular dichroism spectra. All these compounds are first reported from the genus Globba.