distribution of cardiac output
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2016 ◽  
Vol 37 (8) ◽  
pp. 2848-2856 ◽  
Author(s):  
Chang-Yang Xing ◽  
Takashi Tarumi ◽  
Jie Liu ◽  
Yinan Zhang ◽  
Marcel Turner ◽  
...  

A widely accepted dogma is that about 15–20% of cardiac output is received by the brain in healthy adults under resting conditions. However, it is unclear if the distribution of cardiac output directed to the brain alters across the adult lifespan and is modulated by sex or other hemodynamic variables. We measured cerebral blood flow/cardiac output ratio index in 139 subjects (88 women, age 21–80 years) using phase-contrast magnetic resonance imaging and echocardiography. Body mass index, cardiac systolic function (eject fraction), central arterial stiffness (carotid-femoral pulse wave velocity), arterial pressure, heart rate, physical fitness (VO2 max), and total brain volume were measured to assess their effects on the cardiac output–cerebral blood flow relationship. Cerebral blood flow/cardiac output ratio index decreased by 1.3% per decade associated with decreases in cerebral blood flow ( P < 0.001), while cardiac output remained unchanged. Women had higher cerebral blood flow, lower cardiac output, and thus higher cerebral blood flow/cardiac output ratio index than men across the adult lifespan. Age, body mass index, carotid-femoral pulse wave velocity, and arterial pressure all had negative correlations with cerebral blood flow and cerebral blood flow/cardiac output ratio index ( P < 0.05). Multivariable analysis adjusted for sex, age showed that only body mass index was negatively associated with cerebral blood flow/cardiac output ratio index (β = −0.33, P < 0.001). These findings demonstrated that cardiac output distributed to the brain has sex differences and decreases across the adult lifespan and is inversely associated with body mass index.







2007 ◽  
Vol 293 (4) ◽  
pp. H2335-H2343 ◽  
Author(s):  
Satoshi Koba ◽  
Jihong Xing ◽  
Lawrence I. Sinoway ◽  
Jianhua Li

The present study was undertaken to test the hypothesis that activation of the muscle reflex elicits less sympathetic activation in skeletal muscle than in internal organs. In decerebrate rats, we examined renal and lumbar (mainly innervating hindlimb blood vessels) sympathetic nerve activities (RSNA and LSNA, respectively) during 1 min of 1) repetitive (1- to 4-s stimulation-to-relaxation) contraction of the triceps surae muscle, 2) repetitive tendon stretch, and 3) repetitive contraction with hindlimb circulatory occlusion. During these interventions, RSNA and LSNA responded synchronously as tension developed. The increase was greater in RSNA than in LSNA [+51 ± 14 vs. +24 ± 5% ( P < 0.05) with contraction, +46 ± 8 vs. +17 ± 4% ( P < 0.05) with stretch, +76 ± 20 vs. 39 ± 7% ( P < 0.05) with contraction during occlusion] during all three interventions: repetitive contraction ( n = 10, +508 ± 48 g tension from baseline), tendon stretch ( n = 12, +454 ± 34 g), and contraction during occlusion ( n = 9, +473 ± 33 g). Additionally, hindlimb circulatory occlusion significantly enhanced RSNA and LSNA responses to contraction. These data demonstrate that RSNA responses to muscle contraction and stretch are greater than LSNA responses. We suggest that activation of the muscle afferents induces the differential sympathetic outflow that is directed toward the kidney as opposed to the limbs. This differential outflow contributes to the distribution of cardiac output observed during exercise. We further suggest that as exercise proceeds, muscle metabolites produced in contracting muscle sensitize muscle afferents and enhance sympathetic drive to limbs and renal beds.



2007 ◽  
Vol 30 (4) ◽  
pp. 444-444 ◽  
Author(s):  
G. Rizzo ◽  
A. Capponi ◽  
O. Cavicchioni ◽  
M. Vendola ◽  
D. Arduini


2006 ◽  
Vol 290 (1) ◽  
pp. H217-H223 ◽  
Author(s):  
Terese M. Zidon ◽  
Don D. Sheriff

The distribution of cardiac output between compliant vasculature (e.g., splanchnic organs and skin) and noncompliant vasculature (e.g., skeletal muscle) is proposed to constitute an important determinant of the amount of blood available to the heart (central blood volume and pressure). The aim here was to directly test the hypothesis that diversion of blood flow from a relatively noncompliant vasculature (muscle) to compliant vasculature (splanchnic organs and skin) acts to reduce right atrial pressure. The approach was to inflate an occluder cuff on the terminal aorta for 30 s in one of two modes of ventricular pacing in five awake dogs with atrioventricular block and autonomic blockade. In one trial, cardiac output was maintained constant, meaning cuff inflation caused a portion of terminal aortic flow (a noncompliant circulation) to be diverted to the splanchnic and skin circulations (compliant circulations). In the other trial, arterial pressure was maintained constant, meaning blood flow to these other regions did not change. The response of right atrial pressure (corrected for differences in arterial pressure between the two trials) fit our hypothesis, being lower when blood flow was diverted to compliant regions. We conclude that a small (4% of cardiac output) diversion of blood flow from a noncompliant region to a compliant region reduces right atrial pressure by 0.7 mmHg.



2005 ◽  
Vol 130 (4) ◽  
pp. 1062-1070 ◽  
Author(s):  
Marco Ricci ◽  
Pierluca Lombardi ◽  
Alvaro Galindo ◽  
Amelia Vasquez ◽  
Jennifer Zuccarelli ◽  
...  


2005 ◽  
Vol 25 (1_suppl) ◽  
pp. S182-S182
Author(s):  
Takashi Kusaka ◽  
Kenichi Isobe ◽  
Kensuke Okubo ◽  
Keiko Nagano ◽  
Susumu Itoh


2003 ◽  
Vol 22 (S1) ◽  
pp. 58-59 ◽  
Author(s):  
M. Bellotti ◽  
C. De Gasperi ◽  
I. Zucca ◽  
G. Rognoni ◽  
G. Zecca


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