Design, synthesis and anticonvulsant-analgesic activity of new N-[(phenoxy)alkyl]- and N-[(phenoxy)ethoxyethyl]aminoalkanols

New aminoalkanols have been synthesized and evaluated for their anticonvulsant activity in maximal electroshock (MES), maximal electroshock seizure threshold (MEST) and pentylenetetrazol (PTZ) tests, and show promising activity.

Effect of Securigera Securidaca on Electroshock Seizure Threshold in Mice

Finely crushed seeds 100 mg/kg or 250 mg/kg of body weight of Securigera Securidaca or their extracts with petroleum ether, absolute ether or chloroform 100 mg/kg of body weight were administered to albino mice to study their effects on brain excitability. The drugs significantly increased minimal electroshock-brain seizure-threshold. This effect might be due to increase the brain concentration of γ-aminoburyric acid.