Metabolic Status of “Metabolically Normal Obese” Subjects or “MNO”

Metabolic status is dependent on the anthropometric profile; indeed, many obese subjects are "metabolically normal" (MNO or Metabolically Normal Obese) while conversely, other obese or even non-obese subjects are "metabolically abnormal". The topography and the function of the fatty deposits seem to play a determining role in explaining this apparent paradox. In this study are examined the carbohydrate, lipid and liver balance of overweight subjects according to their anthropometric indices. It turns out that generalized obesity where the distribution of fat is diffuse as well as gynoid obesity (gluteo-femoral) are correlated at an almost normal metabolic profile compared to android obesity characterized by the metabolic dysregulations.

Acquired Fanconi Syndrome from Ifosfamide

Fanconi syndrome is a renal proximal tubule defect that causes reabsorption defects of electrolytes. The clinical features of Fanconi syndrome are amino aciduria, proteinuria, hypophosphatemia, metabolic acidosis, and glycosuria. In children, it is usually resulting from a genetic defect, such as cystinosis, galactosemia, tyrosinemia, hereditary fructose intolerance, and Wilson disease [1]. However, in adults, it is usually resulting from medications, toxins, and kidney diseases such as light chain proximal tubulopathy and primary amyloidosis [1]. Ifosfamide is a chemotherapy agent that is well known in the literature to cause Fanconi syndrome. Herein, we present a case of a woman with cervical cancer who developed ifosfamide-induced Fanconi syndrome after her fifth cycle of chemotherapy.

Introducing a New Term: Metastasoptysis- A Case Report

Pulmonary metastasis is not uncommon in the follow-up of patients with primary malignancy, but the expectoration of metastatic tumor is extremely rare. Metastases from renal and breast malignities may rarely lead to tumor expectoration with less common colorectal carcinomas. In this case report, expectoration of a metastatic tumor in a patient who had diagnosed with colon adenocarcinoma and pulmonary metastasis was presented. We named this quite rare condition as “metastasoptysis”.